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Table of Contents
Vol. 33, No. 2, 2011
Issue release date: March 2011
Section title: Original Report: Laboratory Investigation
Am J Nephrol 2011;33:105–110
(DOI:10.1159/000322952)

Docosahexaenoic Acid Is an Independent Predictor of All-Cause Mortality in Hemodialysis Patients

Hamazaki K.a · Terashima Y.b · Itomura M.b · Sawazaki S.c · Inagaki H.d · Kuroda M.d · Tomita S.e · Hirata H.e · Inadera H.a · Hamazaki T.b
aDepartment of Public Health, Faculty of Medicine, and bSection of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama, Toyama City, cHida City Hospital, Hida City, dAsanagi Hospital, Takaoka City, and eJounan Clinic, Toyama City, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Laboratory Investigation

Received: September 20, 2010
Accepted: November 18, 2010
Published online: December 22, 2010
Issue release date: March 2011

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

Background: Dietary n–3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid have been shown to reduce cardiovascular mortality. Patients on hemodialysis (HD) have a very high mortality from cardiovascular disease. Fish consumption reduces all-cause mortality in patients on HD. Moreover, n–3 PUFAs, especially DHA levels in red blood cells (RBCs), are associated with arteriosclerosis in patients on HD. The aim of this study was to determine whether DHA levels in RBCs predict the mortality of patients on HD in a prospective cohort study. Methods: A cohort of 176 patients (64.1 ± 12.0 (mean ± SD) years of age, 96 men and 80 women) under HD treatment was studied. The fatty acid composition of their RBCs was analyzed by gas chromatography. Results: During the study period of 5 years, 54 deaths occurred. After adjustment for 10 confounding factors, the Cox hazard ratio of all-cause mortality of the patients on HD in the highest DHA tertile (>8.1%, 15 deaths) was 0.43 (95% CI 0.21–0.88) compared with those patients in the lowest DHA tertile (<7.2%, 21 deaths). Conclusion: The findings suggest that the level of DHA in RBCs could be an independent predictor of all-cause mortality in patients on HD.

© 2010 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Report: Laboratory Investigation

Received: September 20, 2010
Accepted: November 18, 2010
Published online: December 22, 2010
Issue release date: March 2011

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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