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Cover

Pathogenesis and Management of Atopic Dermatitis

Editor(s): Shiohara T. (Tokyo) 
Table of Contents
Vol. 41, 2011
Section title: Paper
Shiohara T (ed): Pathogenesis and Management of Atopic Dermatitis. Curr Probl Dermatol. Basel, Karger, 2011, vol 41, pp 54–67
(DOI:10.1159/000323296)

The Antimicrobial Skin Barrier in Patients with Atopic Dermatitis

Schittek B.
Department of Dermatology, University of Tübingen, Tübingen, Germany

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: May 12, 2011
Cover Date: 2011

Number of Print Pages: 14
Number of Figures: 1
Number of Tables: 0

ISBN: 978-3-8055-9686-2 (Print)
eISBN: 978-3-8055-9687-9 (Online)

Abstract

Keratinocytes represent the major cell population in the epithelial skin barrier and actively participate in innate immune responses by recognizing pathogenic microorganisms, followed by a fine-tuned production of cytokines, chemokines and antimicrobial peptides or proteins (AMPs). Patients with atopic dermatitis (AD) suffer from a defective permeability barrier which favors pathogen infection indicating that the permeability and antimicrobial barrier functions are interdependent. Several early studies showed that the inducible AMPs LL-37, HBD-2 and HBD-3 are expressed at lower levels in atopic skin compared to psoriatic skin. However, recent data indicate that AMP induction is not compromised in AD patients and that several AMPs are expressed at significantly higher amounts in AD compared to healthy skin. AD patients have an increased susceptibility to Staphylococcus aureus skin infection suggesting that AMP levels expressed by keratinocytes of AD patients might not be sufficient to combat pathogenic skin infection or that AMP function is disturbed. Increasing AMP expression in AD skin and repairing the skin barrier defect might have a therapeutic effect in AD patients enabling the skin to mount an enhanced response to pathogens.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: May 12, 2011
Cover Date: 2011

Number of Print Pages: 14
Number of Figures: 1
Number of Tables: 0

ISBN: 978-3-8055-9686-2 (Print)
eISBN: 978-3-8055-9687-9 (Online)


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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