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Table of Contents
Vol. 3, No. 2, 2011
Issue release date: February 2011
Section title: Review
J Innate Immun 2011;3:120–130

The Effect of Bacterial, Viral and Fungal Infection on Mast Cell Reactivity in the Allergic Setting

McAlpine S.M. · Enoksson M. · Lunderius-Andersson C. · Nilsson G.
Clinical Immunology and Allergy Unit, Department of Medicine, and Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
email Corresponding Author

Dr. Gunnar P. Nilsson, Karolinska Institutet, Department of Medicine

Clinical Immunology and Allergy Unit

Karolinska Universitetssjukhuset Solna, KS L2:04

SE–171 76 Stockholm (Sweden)

Tel. +46 8 517 70 205, Fax +46 8 33 57 24, E-Mail gunnar.p.nilsson@ki.se

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Mast cells are well known for their role in allergic inflammation where, upon aggregation of the high-affinity immunoglobulin E receptor, they release mediators such as histamine that cause classical allergic symptoms. Mast cells are located in almost all tissues and are especially numerous in organs that interface with the environment. Given this strategic location and the more recent notion that they are endowed with receptors that recognize endogenous and exogenous danger signals such as pathogens, it is not surprising that they function as important cells in immune surveillance. When mast cells are activated by pathogens they modulate innate and adaptive immune responses. In allergy, infections might cause exacerbation of the allergic reaction by affecting the reactivity of mast cells. With new developments within the field of mast cell biology, we will better understand how mast cells execute their effector functions. This knowledge will also help to improve the management of allergic diseases.

© 2011 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Review

Received: November 01, 2010
Accepted: December 06, 2010
Published online: January 14, 2011
Issue release date: February 2011

Number of Print Pages: 11
Number of Figures: 2
Number of Tables: 0

ISSN: 1662-811X (Print)
eISSN: 1662-8128 (Online)

For additional information: http://www.karger.com/JIN

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