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Table of Contents
Vol. 18, No. 3, 2011
Issue release date: March 2011
Section title: Original Paper
Neuroimmunomodulation 2011;18:165–170
(DOI:10.1159/000323396)

Long-Term Resistance Training Is Associated with Reduced Circulating Levels of IL-6, IFN-Gamma and TNF-Alpha in Elderly Women

Córdova C.a · Lopes-e-Silva, Jr. F.a · Pires A.S.b · Souza V.C.c · Brito C.J.a · Moraes C.F.b, d · Sposito A.C.e · Nóbrega O.T.c, d
aGraduate Program in Physical Education and Health, bGraduate Program in Gerontology, Catholic University of Brasília, cGraduate Program in Health Sciences and dGraduate Program in Medical Sciences, University of Brasília, Brasília, and eFaculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 17, 2010
Accepted: December 02, 2010
Published online: February 09, 2011
Issue release date: March 2011

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM

Abstract

Objective: The increase in inflammatory activity associated with aging is a characteristic of chronic disease processes that accounts for most of the mortality in the elderly. Resistance training (RT) has been shown to promote metabolic and functional benefits in this population. The objective of this study was to investigate the association between long-term RT and circulating levels of the proinflammatory mediators IL-6, TNF-α and IFN-γ in elderly women. Methods: This cross-sectional study included 54 older outpatients divided into a group that underwent RT (n = 28) for an average of 8.6 ± 0.3 months and a sedentary group (n = 26). Measurements were taken only at the end of the intervention, and cytokine values were log-transformed. Dietary intake was controlled as a confounding factor. Results: The RT group presented reduced levels of log10IFN-γ (approx. 45%; p = 0.003), log10IL-6 (approx. 30%; p = 0.002) and log10TNF-α (approx. 22%; p = 0.036). Total caloric intake and systolic arterial blood pressure were significantly lower in the RT group (p = 0.001 and p = 0.022, respectively). Pearson’s product moment correlation test revealed a negative association between the fat-free mass (FFM) index and log-transformed IL-6 levels (p = 0.03; n = 54) and a trend towards significance for the correlation between the FFM index and log10IFN-γ (p = 0.05; n = 54). Conclusion: Long-term, moderate-intensity RT in elderly women is associated with lower circulating levels of cytokines that are potentially implicated in disorders associated with physical inactivity and aging.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 17, 2010
Accepted: December 02, 2010
Published online: February 09, 2011
Issue release date: March 2011

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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