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Vol. 86, No. 3, 2011
Issue release date: April 2011
Section title: Original Paper
Urol Int 2011;86:298–301
(DOI:10.1159/000323655)

Effect of Cordyceps sinensis on Renal Function of Patients with Chronic Allograft Nephropathy

Zhang Z. · Wang X. · Zhang Y. · Ye G.
aDepartment of Urology, Peking University Shougang Hospital, Beijing, and bDepartment of Urology and Renal Transplantation, Center of Nephropathy, Second Affiliated Hospital, Third Military Medical University, Chongqing, China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/26/2010
Accepted: 11/25/2010
Published online: 2/19/2011

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 4

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Objective: To investigate the effect of Cordyceps sinensis (Bailing Capsule, fermented agent of C. sinensis) on renal function of patients with chronic allograft nephropathy (CAN). Methods: A total of 231 CAN patients who underwent transplantation between 2005 and 2008 and experienced chronic graft dysfunction were randomly divided into 2 groups. Patients in group A (n = 122) were treated with immunosuppressive agents and C. sinensis (2.0 g/day, 3 times a day), while patients in group B (n = 109) were treated with traditional immunosuppressive drugs. Serum creatinine (SCr), blood urea nitrogen (BUN), creatinine clearance rate (CCr) and urinary protein in 24 h (24-hour Upro) of all patients were measured before and after treatment. Urinary concentrations of transforming growth factor (TGF)-β1, retinol-binding protein (RBP) and β2-microglobulin (β2-MG) were detected at the same time. Results: After 6-month treatment with C. sinensis, SCr and CCr in group A were significantly improved (p < 0.05), while there was no significant improvement observed for group B. There was no significant change in BUN in groups A and B (p > 0.05). 24-hour Upro, RBP and β2-MG were lower in group A after treatment with C. sinensis (p < 0.05 or p < 0.01), and urinary TGF-β1 in group A was significantly lower than the values before C. sinensis treatment (p < 0.05), but showed no change in patients of group B. In group A, renal function had improved in 72 cases, stabilized in 38 cases, and worsened in 12 cases. In group B, renal function had improved in 14 cases, stabilized in 50 cases, and worsened in 45 cases (p < 0.05). Conclusion:C. sinensis therapy is advantageous in improving renal function of CAN patients by retarding CAN progression.


  

Author Contacts

Xiangwei Wang
Department of Urology and Renal Transplantation, Center of Nephropathy Second Affiliated Hospital, Third Military Medical University
Chongqing 400037 (China)
Tel. +86 236 877 4624, E-Mail winn0324@sohu.com

  

Article Information

Z. Zhang, X. Wang and Y. Zhang contributed equally to this work.

Received: May 26, 2010
Accepted after revision: November 25, 2010
Published online: February 19, 2011
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 4, Number of References : 15

  

Publication Details

Urologia Internationalis

Vol. 86, No. 3, Year 2011 (Cover Date: April 2011)

Journal Editor: Wirth M.P. (Dresden), Porena M. (Perugia), Hakenberg O.W. (Rostock), Castro-Diaz D. (Santa Cruz de Tenerife)
ISSN: 0042-1138 (Print), eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/26/2010
Accepted: 11/25/2010
Published online: 2/19/2011

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 4

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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