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In vivo Antinociceptive and Anti-inflammatory Activities of Dried and Fermented Processed Virgin Coconut OilZakaria Z.A.a, b · Somchit M.N.a · Mat Jais A.M.a · Teh L.K.b · Salleh M.Z.b · Long K.c
aDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, bPharmacogenomics Center, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, and cBiotechnology Research Centre, Malaysian Agriculture Research Institute, Kuala Lumpur, Malaysia Corresponding Author
Dr. Zainul Amiruddin Zakaria
Department of Biomedical Science, Faculty of Medicine and Health Sciences
Universiti Putra Malaysia
43400 UPM Serdang, Selangor (Malaysia)
Tel. +60 3 8947 2654, Fax +60 3 8943 6178, E-Mail firstname.lastname@example.org
Objective: The present study was carried out to investigate the antinociceptive and anti-inflammatory activities of virgin coconut oil (VCO) produced by theMalaysian Agriculture Research and Development Institute (MARDI) using various in vivo models. Materials and Methods: Two types of VCOs, produced via standard drying (VCOA) and fermentation (VCOB) processes were used in this study. Both VCOA and VCOB were serially diluted using 1% Tween 80 to concentrations (v/v) of 10, 50 and 100%. Antinociceptive and anti- inflammatory activities of both VCOs were examined using various in vivomodel systems. The antinociceptive activity of the VCOs were compared to those of 1% Tween 80 (used as a negative control), morphine (5 mg/kg) and/or acetylsalicylic acid (100 mg/kg). Results: Both VCOA and VCOB exhibited significant (p < 0.05) dose-dependent antinociceptive activity in the acetic acid-induced writhing test. Both VCOs also exerted significant (p < 0.05) antinociceptive activity in both phases of the formalin and hot-plate tests. Interestingly, the VCOs exhibited anti-inflammatory activity in an acute (carrageenan-induced paw edema test), but not in a chronic (cotton-pellet-induced granuloma test) model of inflammation. Conclusion: The MARDI-produced VCOs possessed antinociceptive and anti-inflammatory activities. Further studies are needed to confirm these observations.
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