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Original Research Article

Changes in Vascular Risk Factors from Midlife to Late Life and White Matter Lesions: A 20-Year Follow-Up Study

Vuorinen M.e · Solomon A.a, e · Rovio S.a · Nieminen L.e · Kåreholt I.a · Tuomilehto J.b–d · Soininen H.e–g · Kivipelto M.a, e

Author affiliations

aAging Research Center, NVS, Karolinska Institute, Stockholm, Sweden; bDepartment of Epidemiology and Health Promotion, National Public Health Institute, and cDepartment of Public Health, University of Helsinki, Helsinki, dSouth Ostrobothnia Central Hospital, Seinäjoki, eDepartment of Neurology, School of Medicine, University of Eastern Finland, and fDepartment of Neurology, Kuopio University Hospital, Kuopio, gDepartment of Geriatrics, University of Turku, Turku, Finland

Related Articles for ""

Dement Geriatr Cogn Disord 2011;31:119–125

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: December 17, 2010
Published online: January 27, 2011
Issue release date: March 2011

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background/Aims: This study investigated the relation of midlife blood pressure, total cholesterol, body mass index (BMI), their changes over time, apolipoprotein E, and white matter lesions (WML). Methods: Participants of the Cardiovascular Risk Factors, Aging and Incidence of Dementia study were derived from random, population-based samples previously surveyed in 1972, 1977, 1982 or 1987. In 1998, 1,449 (73%) individuals aged 65–79 years were re-examined (average follow-up 21 years). A subpopulation (n = 112) was scanned with a 1.5-tesla MRI scanner in 1998, and WML were assessed from fluid-attenuated inversion recovery images using a semi-quantitative visual rating scale. Results: Risk of late-life WML was related to midlife overweight (relative risk = 2.53; 95% CI = 1.70–2.89), obesity (2.94; 2.44–3.03), and hypertension (2.73; 1.81–3.08), even after adjustments for several confounding factors. Elevated BMI (>25) (2.26; 1.42–2.62) and hypertension (3.14; 1.83–3.40) from midlife to late life also increased the risk of WML. In addition, an association with WML was seen for decreasing blood pressure (hypertension at midlife but not at late life) (3.25; 2.46–3.41), even after controlling for antihypertensive treatment. Lipid-lowering drugs had a protective effect against WML (0.13; 0.02–0.59). Conclusions: These results indicate that early and sustained vascular risk factor control is associated with a lower likelihood of having more severe WML in late life.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: December 17, 2010
Published online: January 27, 2011
Issue release date: March 2011

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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