Cover

Sepsis - Pro-Inflammatory and Anti-Inflammatory Responses

Good, Bad or Ugly?

Editor(s): Herwald H. (Lund) 
Egesten A. (Lund) 
Table of Contents
Vol. 17, 2011
Section title: Paper
Herwald H, Egesten A (eds): Sepsis – Pro-Inflammatory and Anti-Inflammatory Responses. Contrib Microbiol. Basel, Karger, 2011, vol 17, pp 48–85
(DOI:10.1159/000324009)

Molecular Mechanisms of Sepsis

Russell J.A.a,b · Boyd J.a,b · Nakada T.a · Thair S.a · Walley K.R.a,b
aHeart and Lung Institute and bDivision of Critical Care Medicine, St. Paul’s Hospital, Vancouver, BC, Canada

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/9/2011
Cover Date: 2011

Number of Print Pages: 38
Number of Figures: 7
Number of Tables: 2

ISBN: 978-3-8055-9710-4 (Print)
eISBN: 978-3-8055-9711-1 (Online)

Abstract

In cancer, therapies are targeted at 6 important pathways. In sepsis, there is ongoing controversy regarding the number and relative roles of pathways that are activated or repressed and which are important in the progression from health to death. Adding to complexity, there is interaction of pathways, there are differences in temporal pattern of up and down-regulation of pathways and there are different responses of pathways to therapies of sepsis. In this review, we define four key pathways of sepsis: (1) inflammation and immunity, (2) coagulation and fibrinolysis, (3) apoptosis, and (4) endocrine. Each of these pathways can impair endothelial function, a unifying aspect of the pathophysiology of sepsis. There are few studies of interactions of pathways except for the interacttion of inflammation/immunity with coagulation/fibrinolysis. Successful treatment of cancer requires that cancer therapies interrupt several key pathways of cancer. Accordingly, we suggest that successful treatment of sepsis will require therapies that interrupt several key pathways of sepsis. Perhaps the paucity of approved therapies for sepsis is related in part to the underevaluation of novel pathways, to lack of understanding of interactions of pathways and to lack of interruption of key pathways of sepsis.

© 2011 S. Karger AG, Basel


  

Author Contacts

Dr. James A. Russell, Heart and Lung Institute and Division of Critical Care Medicine, St. Paul’s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6 (Canada), E-Mail Jim.Russell@hli.ubc.ca

  

Article Information

Number of Print Pages : 38

  

Publication Details

Book Serie: Contributions to Microbiology, Vol. 17, Year 2011

Editor(s): Schmidt, A. (Düsseldorf); Herwald, H. (Lund)
ISSN: 1420-9519 (Print), eISSN: 1662-291X (Online)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=1420-9519

Book Title: Sepsis - Pro-Inflammatory and Anti-Inflammatory Responses (Good, Bad or Ugly?)

Editor(s): Herwald H, Egesten A (eds)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=1420-9519&volume=17


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/9/2011
Cover Date: 2011

Number of Print Pages: 38
Number of Figures: 7
Number of Tables: 2

ISBN: 978-3-8055-9710-4 (Print)
eISBN: 978-3-8055-9711-1 (Online)


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