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Table of Contents
Vol. 3, No. 3, 2011
Issue release date: April 2011
Section title: Review
Free Access
J Innate Immun 2011;3:274–279

Natural Killer Cell Responses to Viral Infection

Brandstadter J.D.a · Yang Y.a, b
aMolecular Cancer Biology Program and bDepartment of Medicine, Duke University Medical Center, Durham, N.C., USA
email Corresponding Author

Dr. Yiping Yang

Department of Medicine

Duke University Medical Center

Box 103005, Durham, NC 27710 (USA)

Tel. +1 919 668 0932, E-Mail yang0029@mc.duke.edu

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Natural killer (NK) cells, as part of the innate immune system, play a key role in host defense against viral infections. Recent advances have indicated that NK cell activation and function are regulated by the interplay between inhibitory and activating signals. Thus, a better understanding of mechanisms responsible for NK cell activation and function in the control of viral infections will help develop NK cell-based therapies. In this review, we will first discuss how NK cells are activated in response to viral infections. We will then focus on the recruitment of activated NK cells to the site of infection as well as on NK cell effector mechanisms against virally infected cells.

© 2011 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Review

Received: October 31, 2010
Accepted: January 11, 2011
Published online: March 12, 2011
Issue release date: April 2011

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1662-811X (Print)
eISSN: 1662-8128 (Online)

For additional information: http://www.karger.com/JIN

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