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Vol. 20, No. 1, 2011
Issue release date: March 2011
Section title: Research Article
J Mol Microbiol Biotechnol 2011;20:24–28
(DOI:10.1159/000324331)

Mycobacterial Strains That Stimulate the Immune System Most Efficiently as Candidates for the Treatment of Bladder Cancer

Yuksel Z.S.a · Buber E.b · Kocagoz T.d · Alp A.c · Saribas Z.c · Acan N.L.b
aDepartment of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, Departments of bMedical Biochemistry and cMedical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, and dDepartment of Medical Microbiology, Faculty of Medicine, Acibadem University, Istanbul, Turkey

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Article / Publication Details

First-Page Preview
Abstract of Research Article

Published online: 2/19/2011
Issue release date: March 2011

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1464-1801 (Print)
eISSN: 1660-2412 (Online)

For additional information: http://www.karger.com/MMB

Abstract

Background: Intravesical bacillus Calmette-Guérin (BCG) application is widely used in the treatment of superficial bladder carcinoma. Despite being an effective therapy, the pathogenicity and lethal side effects of BCG limits its usage. Intensive research has been carried out to find less toxic and more potent therapeutic agents for the treatment of bladder cancer. Researchers have focused on Mycobacterium phlei as an alternative. The cell wall extract of M. phlei is sufficient for antitumoral activity. Our preliminary experiments indicate that the fractions rich in cell wall proteins cause activation of tumor necrosis factor (TNF)-α and interleukin (IL)-12. This study aims to identify powerful and less harmful mycobacteria among 88 strains in terms of how they stimulate the immune system. Methods: Eighty-eight mycobacterial strains were grown in Middlebrook 7H9 medium. The bacterial cells were sonicated after heat treatment. The supernatants were incubated with the monocytic cell line THP-1, followed by measurement of TNF-α and IL-12 response. Results and Conclusion: In addition to M. phlei, the following 12 mycobacterial strains were selected as candidates for superficial bladder tumor treatment: M. agri, M. aichiense, M. aurum, M. brumae, M. chitae, M. chubuense, M. diernhoferi, M. gadium, M. murale, M. obuense, M. tokaiense and M. vaccae.

© 2011 S. Karger AG, Basel


  

Author Contacts

N. Leyla Acan
Department of Medical Biochemistry
Faculty of Medicine, Hacettepe University
TR–06100 Ankara (Turkey)
Tel. +90 312 3051 652/124, E-Mail nla@hacettepe.edu.tr

  

Article Information

Published online: February 19, 2011
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 2, Number of References : 22

  

Publication Details

Journal of Molecular Microbiology and Biotechnology

Vol. 20, No. 1, Year 2011 (Cover Date: March 2011)

Journal Editor: Saier Jr. M.H. (La Jolla, Calif.)
ISSN: 1464-1801 (Print), eISSN: 1660-2412 (Online)

For additional information: http://www.karger.com/MMB


Article / Publication Details

First-Page Preview
Abstract of Research Article

Published online: 2/19/2011
Issue release date: March 2011

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1464-1801 (Print)
eISSN: 1660-2412 (Online)

For additional information: http://www.karger.com/MMB


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