Effects of Mycophenolate Mofetil Combined with Corticosteroids for Induction Therapy of Microscopic PolyangiitisHan F. · Liu G. · Zhang X. · Li X. · He Q. · He X. · Li Q. · Wang S. · Wang H. · Chen J.
Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, PR China
Aims: We prospectively compared the effects of oral mycophenolate mofetil (MMF) or intravenous cyclophosphamide (IVC) combined with corticosteroids for induction therapy of microscopic polyangiitis (MPA) with renal involvement over a follow-up period of 6 months. Methods: 41 MPA patients were randomly assigned to either the open-label MMF group or the IVC group. Patients in the MMF group (n = 19) received oral MMF 1.0 g/day (1.5 g/day for patients with a body weight >70 kg) and patients in the IVC group (n = 22) received IVC in monthly pulses of 1.0 g per pulse (0.8 g per pulse for patients with a body weight <50 kg). Both groups received intravenous methylprednisolone 360–500 mg/day for 3 days, followed by oral prednisone 0.6–0.8 mg/kg/day and gradual tapering. Results: There was no significant difference of estimated glomerular filtration rate (eGFR) level between the IVC and MMF groups at baseline. At 6 months, the eGFR level increased significantly in both groups, but there was no significant difference between the two. Three patients in the IVC group and 1 in the MMF group received maintenance dialysis within 6 months (p = 0.36). The remission rate was 63.6% in the IVC group and 78.9% in the MMF group (p = 0.23). Conclusion: MMF is effective for inducing remission in Chinese MPA patients and may represent an alternative therapy to monthly impulses of IVC.
© 2011 S. Karger AG, Basel
Kidney Disease Center, The First Affiliated Hospital
College of Medicine, Zhejiang University
79 Qingchun Road, Hangzhou, Zhejiang 310003 (PR China)
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F. Han and G. Liu contributed equally to this study.
Received: December 9, 2010
Accepted: January 12, 2011
Published online: February 11, 2011
Number of Print Pages : 8
Number of Figures : 6, Number of Tables : 3, Number of References : 28
American Journal of Nephrology
Vol. 33, No. 2, Year 2011 (Cover Date: March 2011)
Journal Editor: Bakris G. (Chicago, Ill.)
ISSN: 0250-8095 (Print), eISSN: 1421-9670 (Online)
For additional information: http://www.karger.com/AJN