Effects of Mycophenolate Mofetil Combined with Corticosteroids for Induction Therapy of Microscopic PolyangiitisHan F. · Liu G. · Zhang X. · Li X. · He Q. · He X. · Li Q. · Wang S. · Wang H. · Chen J.
Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, PR China
Aims: We prospectively compared the effects of oral mycophenolate mofetil (MMF) or intravenous cyclophosphamide (IVC) combined with corticosteroids for induction therapy of microscopic polyangiitis (MPA) with renal involvement over a follow-up period of 6 months. Methods: 41 MPA patients were randomly assigned to either the open-label MMF group or the IVC group. Patients in the MMF group (n = 19) received oral MMF 1.0 g/day (1.5 g/day for patients with a body weight >70 kg) and patients in the IVC group (n = 22) received IVC in monthly pulses of 1.0 g per pulse (0.8 g per pulse for patients with a body weight <50 kg). Both groups received intravenous methylprednisolone 360–500 mg/day for 3 days, followed by oral prednisone 0.6–0.8 mg/kg/day and gradual tapering. Results: There was no significant difference of estimated glomerular filtration rate (eGFR) level between the IVC and MMF groups at baseline. At 6 months, the eGFR level increased significantly in both groups, but there was no significant difference between the two. Three patients in the IVC group and 1 in the MMF group received maintenance dialysis within 6 months (p = 0.36). The remission rate was 63.6% in the IVC group and 78.9% in the MMF group (p = 0.23). Conclusion: MMF is effective for inducing remission in Chinese MPA patients and may represent an alternative therapy to monthly impulses of IVC.
Kidney Disease Center, The First Affiliated Hospital
College of Medicine, Zhejiang University
79 Qingchun Road, Hangzhou, Zhejiang 310003 (PR China)
Tel. +86 571 8723 6992, E-Mail firstname.lastname@example.org
F. Han and G. Liu contributed equally to this study.
Received: December 9, 2010
Accepted: January 12, 2011
Published online: February 11, 2011
Number of Print Pages : 8
Number of Figures : 6, Number of Tables : 3, Number of References : 28
American Journal of Nephrology
Vol. 33, No. 2, Year 2011 (Cover Date: March 2011)
Journal Editor: Bakris G. (Chicago, Ill.)
ISSN: 0250-8095 (Print), eISSN: 1421-9670 (Online)
For additional information: http://www.karger.com/AJN