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Vol. 87, No. 1, 2011
Issue release date: August 2011
Section title: Original Paper
Urol Int 2011;87:28–34
(DOI:10.1159/000324478)

Optimal Duration of Androgen Deprivation in Combination with Radiation Therapy for Japanese Men with High-Risk Prostate Cancer

Takaha N. · Okihara K. · Kamoi K. · Kimura Y. · Yamada T. · Kawauchi A. · Kobayashi K. · Yamazaki H. · Nishimura T. · Miki T.
Departments of aUrology, bTranslational Cancer Drug Development and cRadiology, Kyoto Prefectural University of Medicine, Kyoto, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/25/2010
Accepted: 1/19/2011
Published online: 6/23/2011

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 4

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Objectives: To evaluate the efficacy and toxicity of external beam radiation therapy (EBRT) combined with androgen deprivation therapy (ADT) for Japanese high-risk prostate cancer (PCa) patients in a single institution. Methods: Seventy-five high-risk PCa patients were treated by three-dimensional conformal radiotherapy of 70 Gy combined with neoadjuvant, concurrent and adjuvant ADT. Results: Median age was 72 (59–82) years. Median initial serum prostate-specific antigen (PSA) was 19.0 (4.7–200) ng/ml. Median duration of the entire ADT was 27 (8–63) months. Median follow-up after initiating ADT and after completing EBRT was 66 (41–105) and 59 (36–94) months, respectively. Five-year overall, clinical progression-free, and biochemical progression-free survival rates were 98.3, 97.2, and 87.4%; 2 (2.7%) cancer deaths, 3 (4.0%) clinical progressions, and 11 (14.7%) biochemical progressions. Multivariate analysis suggested a total duration of ADT shorter than 24 months as an independent risk factor of biochemical progression (p = 0.01). Grade 3 toxicities related to EBRT were observed: 1 patient with proctitis and rectal bleeding and 1 patient with rectal bleeding. Conclusions: It is suggested that 70 Gy EBRT combined with ADT confers disease-free survival benefit with tolerable adverse events for Japanese high-risk PCa patients. ADT of 24 months or longer might be recommended to minimize biochemical progression.


  

Author Contacts

Natsuki Takaha
Departments of Urology and Translational Cancer Drug Development
Kyoto Prefectural University of Medicine
Kawaramachi Hirokoji, Kyoto 602-8566 (Japan)
Tel. +81 75 251 5595, E-Mail ntakaha@koto.kpu-m.ac.jp

  

Article Information

Received: May 25, 2010
Accepted after revision: January 19, 2011
Published online: June 23, 2011
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 4, Number of References : 20

  

Publication Details

Urologia Internationalis

Vol. 87, No. 1, Year 2011 (Cover Date: August 2011)

Journal Editor: Wirth M.P. (Dresden), Porena M. (Perugia), Hakenberg O.W. (Rostock), Castro-Diaz D. (Santa Cruz de Tenerife)
ISSN: 0042-1138 (Print), eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/25/2010
Accepted: 1/19/2011
Published online: 6/23/2011

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 4

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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