Cover

Recent Advances in Tonsils and Mucosal Barriers of the Upper Airways

7th International Symposium on Tonsils and Mucosal Barriers of the Upper Airways, Asahikawa, July 2010: Proceedings

Editor(s): Harabuchi Y. (Asahikawa) 
Hayashi T. (Asahikawa) 
Katada A. (Asahikawa) 
Table of Contents
Vol. 72, 2011
Section title: Innate Immunology
Harabuchi Y (ed): Recent Advances in Tonsils and Mucosal Barriers of the Upper Airways. Adv Otorhinolaryngol. Basel, Karger, 2011, vol 72, pp 93–96
(DOI:10.1159/000324622)

Role of Biofilms in Chronic Inflammatory Diseases of the Upper Airways

Calò L. · Passàli G.C. · Galli J. · Fadda G. · Paludetti G.
Institutes of aOtorhinolaringology and b Microbiology, Catholic University of the Sacred Heart, Rome, Italy

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Article / Publication Details

First-Page Preview
Abstract of Innate Immunology

Published online: 8/18/2011
Cover Date: 2011

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISBN: 978-3-8055-9722-7 (Print)
eISBN: 978-3-8055-9723-4 (Online)

Abstract

The objective of our studies was to document the presence of bacterial biofilms in recurrent and chronic infectious diseases of the upper airways (UA) (adenoiditis, tonsillitis, chronic rhinosinusitis) and to assess the association between the presence of biofilm and the maintenance of a chronic inflammation. Methods: 16 surgical samples of tonsils and adenoids from patients with UA infections and 24 samples of ethmoid mucosa from patients who underwent endoscopic sinus surgery for chronic rhinosinusitis (CRS) were cultured using conventional methods and subjected to scanning electron microscopy (SEM) to detect evidence of biofilm. Results: Bacterial biofilms were observed in 57.5% of chronically infected UA mucosa; in 41.7% of ethmoid mucosa of CRS patients they were significantly (p < 0.001) associated with a marked destruction of ciliated epithelium. Discussion: Our studies confirm that biofilm formation plays a role in UA infections, it not only explains the resistance of these infections to antibiotic therapy, but also represents an important element that contributes to the maintenance of a chronic inflammatory reaction.


  

Author Contacts

Giulio Cesare Passàli, Institute of Otorhinolaringology, Catholic University of the Sacred Heart, p.le A. Gemelli 1, IT-00168 Rome (Italy), Tel. +39 3331727194, E-Mail giulio.passali@rm.unicatt.it

  

Article Information

Published online: August 18, 2011
Number of Print Pages : 4

  

Publication Details

Book Serie: Advances in Oto-Rhino-Laryngology, Vol. 72, Year 2011

Editor(s): Randolph, G. (Boston, Mass.)
ISSN: 0065-3071 (Print), eISSN: 1662-2847 (Online)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=0065-3071

Book Title: Recent Advances in Tonsils and Mucosal Barriers of the Upper Airways (7th International Symposium on Tonsils and Mucosal Barriers of the Upper Airways, Asahikawa, July 2010: Proceedings)

Editor(s): Harabuchi Y (ed)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=0065-3071&volume=72


Article / Publication Details

First-Page Preview
Abstract of Innate Immunology

Published online: 8/18/2011
Cover Date: 2011

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISBN: 978-3-8055-9722-7 (Print)
eISBN: 978-3-8055-9723-4 (Online)


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