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Milk and Milk Products in Human Nutrition

67th Nestlé Nutrition Institute Workshop, Pediatric Program, Marrakech, March 2010

Editor(s): Clemens R.A. (Los Angeles, Calif.) 
Hernell O. (Umeå) 
Michaelsen K.F. (Copenhagen) 
Table of Contents
Vol. 67, No. , 2011
Section title: General Aspects of Milk: Milk in Adult Nutrition
Clemens RA, Hernell O, Michaelsen KF (eds): Milk and Milk Products in Human Nutrition. Nestlé Nutr Inst Workshop Ser Pediatr Program, vol 67, pp 187–195, Nestec Ltd., Vevey/S. Karger AG, Basel, © 2011
(DOI:10.1159/000325584)

Milk A1 and A2 Peptides and Diabetes

Clemens R.A.
Regulatory Science, School of Pharmacy, University of Southern California, Los Angeles, CA, USA

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Article / Publication Details

First-Page Preview
Abstract of General Aspects of Milk: Milk in Adult Nutrition

Published online: 2/16/2011
Cover Date: 2011

Number of Print Pages: 0
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9586-5 (Print)
eISBN: 978-3-8055-9587-2 (Online)

Abstract

Food-derived peptides, specifically those derived from milk, may adversely affect health by increasing the risk of insulin-dependent diabetes. This position is based on the relationship of type 1 diabetes (T1D) and the consumption of variants A1 and B β-casein from cow’s milk. It appears that β-casomorphin-7 (BCM-7) from β-casein may function as an immunosuppressant and impair tolerance to dietary antigens in the gut immune system, which, in turn, may contribute to the onset of T1D. There are thirteen genetic variants of β-casein in dairy cattle. Among those variants are A1, A2, and B, which are also found in human milk. The amino acid sequences of β-casomorphins among these bovine variants and those found in human milk are similar, often differing only by a single amino acid. In vitro studies indicate BCM-7 can be produced from A1 and B during typical digestive processes; however, BCM-7 is not a product of A2 digestion. Evidence from several epidemiological studies and animal models does not support the association of milk proteins, even proteins in breast milk, and the development of T1D. Ecological data, primarily based on A1/ A2 variations among livestock breeds, do not demonstrate causation, even among countries where there is considerable dairy consumption.


  

Article Information

Number of Print Pages : 9

  

Publication Details

Book Serie: Nestlé Nutrition Institute Workshop Series: Pediatric Program, Vol. 67, Year 2011 ISSN: 1661-6677 (Print), eISSN: 1662-3878 (Online)

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Book Title: Milk and Milk Products in Human Nutrition (67th Nestlé Nutrition Institute Workshop, Pediatric Program, Marrakech, March 2010)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=1661-6677&volume=67


Article / Publication Details

First-Page Preview
Abstract of General Aspects of Milk: Milk in Adult Nutrition

Published online: 2/16/2011
Cover Date: 2011

Number of Print Pages: 0
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9586-5 (Print)
eISBN: 978-3-8055-9587-2 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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