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Table of Contents
Vol. 38, No. 2, 2011
Issue release date: April 2011
Section title: Review Article · Übersichtsarbeit
Free Access
Transfus Med Hemother 2011;38:143–147
(DOI:10.1159/000326632)

Preservation of Human Cornea

Armitage W.J.
School of Clinical Sciences, University of Bristol, UK
email Corresponding Author

Prof. Dr. W. John Armitage, CTS Bristol Eye Bank, University of Bristol, Bristol Eye Hospital, Lower Maudlin Street, Bristol BS1 2LX, UK, Tel. +44 117-342 4585, Fax -904 6624, w.j.armitage@bristol.ac.uk

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Abstract

The successful outcome of the majority of corneal transplants depends on the presence of a viable corneal endothelium. This monolayer of cells lines the inner surface of the cornea and its primary function is to maintain corneal transparency by controlling the hydration of the collagenous stromal layer. Since human corneal endothelial cells do not readily proliferate, preservation of the endothelium is a primary aim of methods of corneal storage. Although some cryopreserved corneas have been transplanted successfully, the complexity of the cryopreservation technique and its potential for causing endothelial damage have limited its application. Hypothermia (2–8°C) is the most commonly applied method of storage, which allows storage for 7–14 days. Organ culture (28–37°C), which extends storage time to 4 weeks, is used widely in European eye banks. Graft outcomes for corneas stored by these two techniques appear similar.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review Article · Übersichtsarbeit

Received: January 10, 2011
Accepted: January 25, 2011
Published online: March 16, 2011
Issue release date: April 2011

ISSN: 1660-3796 (Print)
eISSN: 1660-3818 (Online)

For additional information: http://www.karger.com/TMH


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