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Vol. 31, No. 4, 2011
Issue release date: May 2011
Section title: Original Research Article
Dement Geriatr Cogn Disord 2011;31:254–258
(DOI:10.1159/000327169)

Screening for Cognitive Dysfunction in Corticobasal Syndrome: Utility of Addenbrooke’s Cognitive Examination

Mathew R. · Bak T.H. · Hodges J.R.
aNeuroscience Research Australia (Previously Prince of Wales Medical Research Institute), Sydney, N.S.W., Australia; bSchool of Psychology, Edinburgh University, Edinburgh, UK; cDepartment of Neurology, Government Medical College, Trivandrum, India; dUniversity of New South Wales, Sydney, N.S.W., Australia

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 3/8/2011
Published online: 4/8/2011

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Introduction: The motor features of corticobasal syndrome (CBS) are well recognized but the fact that many, if not all, affected patients develop cognitive impairment is still underrecognized. The dementia of CBS overlaps most with a language variant of frontotemporal dementia: progressive nonfluent aphasia (PNFA). The aim of this study was to determine the usefulness of Addenbrooke’s Cognitive Examination-Revised (ACE-R) in the evaluation of CBS and to document similarities and differences between CBS and PNFA. Materials and Methods: Patients with well-defined CBS or PNFA from two tertiary referral centers were selected along with matched controls. Results: Twenty-one patients with CBS, 23 patients with PNFA and 47 age- and education- matched controls were included. Both CBS and PNFA groups showed substantial impairment on the ACE-R (f = 17.3–80.2, p < 0.001) and were significantly impaired in all domains (p < 0.001). The only significant difference between CBS and PNFA was in the visuospatial domain (p < 0.009), being worse in CBS. Using a cutoff of 88/89 out of 100, 90% of CBS and 82.6% of PNFA patients were impaired. At this cutoff of 88/89, ACE-R in CBS had sensitivity and specificity values of 91 and 98%, respectively.


  

Author Contacts

Prof. John R. Hodges
Neuroscience Research Australia
(Previously Prince of Wales Medical Research Institute)
Barker Street, Randwick, NSW 2031 (Australia)
Tel. +61 2 9399 1132, E-Mail j.hodges@neura.edu.au

  

Article Information

Accepted: March 8, 2011
Published online: April 8, 2011
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 2, Number of References : 25

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 31, No. 4, Year 2011 (Cover Date: May 2011)

Journal Editor: Chan-Palay V. (Boston, Mass.)
ISSN: 1420-8008 (Print), eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 3/8/2011
Published online: 4/8/2011

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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