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Vol. 31, No. 4, 2011
Issue release date: May 2011
Section title: Original Research Article
Dement Geriatr Cogn Disord 2011;31:247–253
(DOI:10.1159/000327171)

Genetic Associations of Autopsy-Confirmed Vascular Dementia Subtypes

Jones E.L.a · Kalaria R.N.b · Sharp S.I.c · O’Brien J.T.b · Francis P.T.a · Ballard C.G.a
aWolfson CARD, King’s College London, London, bInstitute for Ageing and Health, Campus for Ageing and Vitality, Wolfson Research Centre, University of Newcastle, Newcastle upon Tyne, and cWindeyer Institute for Medical Sciences, University College London, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 3/7/2011
Published online: 4/7/2011
Issue release date: May 2011

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background/Aims: Genetic risk factors have not been clearly established for vascular dementias (VaD) related to stroke and cerebrovascular disease. Methods: Samples were genotyped for APOE, MTHFR and ICAM. Aβ levels and choline acetyltransferase (ChAT) activities were assayed in controls and individuals with VaD. Results: Associations were found between the APOE-ε4 allele and mixed dementia, infarct/stroke dementia and subcortical ischemic vascular dementia (SIVD), and higher Aβ1-42 levels and decreased ChAT activity. MTHFR was more associated with SIVD, mixed dementia, and lower ChAT activity. Conclusions: The study demonstrates important differences in the genetic associations of VaD and begins to clarify the genetic basis of key pathological substrates.


  

Author Contacts

Emma L. Jones
Wolfson CARD, King’s College London
Guy’s Campus, London SE1 1UL (UK)
Tel. +44 207 848 6171
E-Mail emma.3.jones@kcl.ac.uk

  

Article Information

Accepted: March 7, 2011
Published online: April 7, 2011
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 1, Number of References : 46

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 31, No. 4, Year 2011 (Cover Date: May 2011)

Journal Editor: Chan-Palay V. (Boston, Mass.)
ISSN: 1420-8008 (Print), eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 3/7/2011
Published online: 4/7/2011
Issue release date: May 2011

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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