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Table of Contents
Vol. 65, No. 6, 2011
Issue release date: June 2011
Section title: Original Paper
Eur Neurol 2011;65:340–345
(DOI:10.1159/000327213)

Hemodynamic Impact of Fetal-Variant Willisian Circle on Cerebral Circulation: A Duplex Ultrasonography Study

Hong J.M. · Lee J.S. · Shin D.H. · Yong S.W.
Department of Neurology, Ajou University School of Medicine, Suwon, South Korea

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 12, 2010
Accepted: March 08, 2011
Published online: May 19, 2011
Issue release date: June 2011

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

Background/Aims: The Willisian circle can redistribute the vertebrobasilar flow and the reduction of flow is attributable to orthrostatic presyncope. To evaluate this hemodynamic aspect, we investigated anterior and posterior cerebral blood flow (CBF) volume distributions according to the variation of the Willisian circle, and compared those between controls and patients with presyncope. Methods: Subjects underwent cerebral CT angiography and color-coded duplex sonography measuring flow volumes of the internal carotid artery (ICAs) and vertebral artery (VAs). According to clinical manifestations and Willisian configurations, CBF volume patterns were analyzed. Results: Between the presyncope (n = 25) and control groups (n = 76), the prevalence of fetal-variant Willisian configuration (48% vs. 21%, p = 0.004) and posterior CBF volume (126 ± 85 vs. 165 ± 64 ml/min, p = 0.015) was significantly different, but A1 morphology, anterior CBF, and total CBF volumes were not. Total CBF volume was 769 ± 176 ml/min (80% ICAs and 20% VAs). The posterior CBF volume lowered significantly (172 ± 70 vs. 122 ± 62 vs. 92 ± 44 ml/min; p < 0.001) toward the two-sided fetal type variation, although total CBF volume is similar among the three groups (p = 0.742). Conclusions: The present study suggests that Willisian configuration contributes to orthostatic presyncope and flow distribution of the cerebral circulation.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 12, 2010
Accepted: March 08, 2011
Published online: May 19, 2011
Issue release date: June 2011

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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