Well-Differentiated Liposarcoma, an Atypical Lipomatous Tumor, of the Mesentery: A Case Report and Review of the LiteratureYuri T.a · Miyaso T.b · Kitade H.b · Takasu K.c · Shikata N.c · Takada H.b · Tsubura A.a
aDepartment of Pathology II, Kansai Medical University, and Divisions of bSurgery and cClinical Laboratory and Science, Kansai Medical University, Takii Hospital, Moriguchi, Japan Corresponding Author
Department of Pathology II Kansai Medical University
Moriguchi 570-8506 (Japan)
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Mesenteric liposarcoma is a rare neoplasm. Here, we report the case of a 73-year-old Japanese man with a well-differentiated (WD) liposarcoma of the mesentery. Due to rapid growth of the abdominal mass and abdominal insufficiency, a tumorectomy was performed. The excised tumor was 12.4 × 9.6 cm in size and weighed 548 g. Cut sections showed a lobulated yellow and/or grayish-colored appearance. The histological features were predominantly those of the sclerotic and lipoma-like variants of WD liposarcoma. The cytoplasm of most spindle cells was diffusely immunoreactive for CD34, while fat cells were positive for S-100 protein. Some spindle cell nuclei were positive for CDK4, and a few were positive for MDM2. The average Ki-67 proliferation index in tumor cells was 10%, and androgen receptor expression was detected in tumor cell nuclei. The present case and 11 cases identified from a literature search were reviewed. The WD mesenteric liposarcomas developed in patients in the fourth to seventh decades of life (mean age 57.9 years). The patients consisted of 7 men and 5 women. All tumors were larger than 10 cm in diameter at the time of surgery. Complete resection might be the only curative therapy for WD liposarcomas of the mesentery, but long-term follow-up is needed because of the possibility of a local recurrence of the tumor.
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