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Table of Contents
Vol. 18, No. 2, 2011
Issue release date: April 2011
Section title: Original Article · Originalarbeit
Forsch Komplementmed 2011;18:77–83
(DOI:10.1159/000327306)

Efficacy and Safety of Rhus verniciflua Stokes Extracts in Patients with Previously Treated Advanced Non-Small Cell Lung Cancer

Cheon S.H.a · Kim K.S.b · Kim S.c · Jung H.S.b · Choi W.C.b · Eo W.K.a
a Department of Internal Medicine, M×µ Integrative Cancer Center, East West Neo Medical Center, Kyung Hee University College of Medicine, b Department of Oriental Oncology, M×µ Integrative Cancer Center, East West Neo Medical Center, Kyung Hee University College of Oriental Medicine, c Graduate School of East West Medical Science, Kyung Hee University, Seoul, Korea

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Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: April 04, 2011
Issue release date: April 2011

ISSN: 1661-4119 (Print)
eISSN: 1661-4127 (Online)

For additional information: http://www.karger.com/FOK

Abstract

Background: Systemic treatments for advanced non-small cell lung cancer (NSCLC) have modest survival benefits but high toxicity. Rhus verniciflua Stokes (RVS), the lacquer tree, is an ancient traditional medicine being used for the treatment of cancer. We investigated the efficacy and safety of allergen-removed RVS extract (aRVS) for the prolongation of survival in NSCLC after the failure of first-line or secondline chemotherapy. Patients and Methods: We reviewed the medical records of 40 patients who were treated with aRVS for previously treated, advanced NSCLC at the M×µ Integrative Cancer Center, Korea, between June 2006 and June 2009. The primary objective of this study was to assess overall survival. Secondary objectives included assessments of disease control rates, progression-free survival, and the safety of aRVS treatment. Results: The median survival time was 8.4 months with a 1-year survival of 40%. The disease control rate was 63.6%, and the median progression-free survival interval was 3.9 months. Patients who had better performance status and adenocarcinoma experienced more favorable outcomes in terms of overall survival. in aRVS treatment were negligible, with the most common drug-related adverse events being mild epigastric pain and itching skin. Hematologic toxicity was absent. Conclusions: Survival data and favorable levels of tolerability suggest the potential of aRVS treatment in previously treated patients with advanced NSCLC. Treatment with aRVS might be a viable alternative in patients for whom chemotherapy is not feasible, or who refuse chemotherapy.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: April 04, 2011
Issue release date: April 2011

ISSN: 1661-4119 (Print)
eISSN: 1661-4127 (Online)

For additional information: http://www.karger.com/FOK


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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