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Vol. 31, No. 4, 2011
Issue release date: May 2011
Section title: Original Research Article
Dement Geriatr Cogn Disord 2011;31:309–316
(DOI:10.1159/000327360)

Prevalence and Pathology of Dementia with Lewy Bodies in the Oldest Old: A Comparison with Other Dementing Disorders

Jellinger K.A. · Attems J.
aInstitute of Clinical Neurobiology, Vienna, Austria; bInstitute for Ageing and Health, Wolfson Research Centre, Newcastle upon Tyne, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 3/14/2011
Published online: 4/20/2011

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background: While the prevalence of Alzheimer disease (AD) increases with age, little is known about the frequency of dementia with Lewy bodies (DLB) in the oldest old. A retrospective hospital-based study compared the relative prevalence of DLB among very old individuals. Methods: 1,100 consecutive autopsy cases of demented patients aged over 70 years (mean age: 83.9 ± 5.4 years) were examined using standardized neuropathological methods and current diagnostic consensus criteria. Results: Evaluation of three age groups (8th–10th decade) showed a significant increase in the relative prevalence of AD with cerebrovascular lesions including mixed dementia, while AD with Lewy body (LB) pathology showed a mild but insignificant age-related increase. Both ‘pure’ AD and vascular dementia showed a mild but insignificant decline, while DLB (without severe AD pathology) decreased progressively. While the severity of Lewy pathology in DLB slightly decreased with age, concomitant Alzheimer-like pathology increased progressively. Conclusion: Whether DLB in the oldest old represents a distinct group is a matter of discussion, but the relative prevalence of AD with LB in our sample remained fairly stable.


  

Author Contacts

Kurt A. Jellinger
Institute of Clinical Neurobiology
Kenyongasse 18
AT–1070 Vienna (Austria)
Tel. +43 1 526 6534, E-Mail kurt.jellinger@univie.ac.at

  

Article Information

Accepted: March 14, 2011
Published online: April 20, 2011
Number of Print Pages : 8
Number of Figures : 2, Number of Tables : 2, Number of References : 76

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 31, No. 4, Year 2011 (Cover Date: May 2011)

Journal Editor: Chan-Palay V. (Boston, Mass.)
ISSN: 1420-8008 (Print), eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 3/14/2011
Published online: 4/20/2011

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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