Prevalence and Pathology of Dementia with Lewy Bodies in the Oldest Old: A Comparison with Other Dementing DisordersJellinger K.A. · Attems J.
aInstitute of Clinical Neurobiology, Vienna, Austria; bInstitute for Ageing and Health, Wolfson Research Centre, Newcastle upon Tyne, UK
Background: While the prevalence of Alzheimer disease (AD) increases with age, little is known about the frequency of dementia with Lewy bodies (DLB) in the oldest old. A retrospective hospital-based study compared the relative prevalence of DLB among very old individuals. Methods: 1,100 consecutive autopsy cases of demented patients aged over 70 years (mean age: 83.9 ± 5.4 years) were examined using standardized neuropathological methods and current diagnostic consensus criteria. Results: Evaluation of three age groups (8th–10th decade) showed a significant increase in the relative prevalence of AD with cerebrovascular lesions including mixed dementia, while AD with Lewy body (LB) pathology showed a mild but insignificant age-related increase. Both ‘pure’ AD and vascular dementia showed a mild but insignificant decline, while DLB (without severe AD pathology) decreased progressively. While the severity of Lewy pathology in DLB slightly decreased with age, concomitant Alzheimer-like pathology increased progressively. Conclusion: Whether DLB in the oldest old represents a distinct group is a matter of discussion, but the relative prevalence of AD with LB in our sample remained fairly stable.
Kurt A. Jellinger
Institute of Clinical Neurobiology
AT–1070 Vienna (Austria)
Tel. +43 1 526 6534, E-Mail firstname.lastname@example.org
Accepted: March 14, 2011
Published online: April 20, 2011
Number of Print Pages : 8
Number of Figures : 2, Number of Tables : 2, Number of References : 76
Dementia and Geriatric Cognitive Disorders
Vol. 31, No. 4, Year 2011 (Cover Date: May 2011)
Journal Editor: Chan-Palay V. (Boston, Mass.)
ISSN: 1420-8008 (Print), eISSN: 1421-9824 (Online)
For additional information: http://www.karger.com/DEM