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Table of Contents
Vol. 19, No. 3, 2011
Issue release date: August 2011
Section title: Original Paper
Neurosignals 2011;19:128–141

Targeted Deletion of CASK-Interacting Nucleosome Assembly Protein Causes Higher Locomotor and Exploratory Activities

Chung W.-C.a, b · Huang T.-N.b · Hsueh Y.-P.a, b
aGraduate Institute of Life Sciences, National Defense Medical Center, and bInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC
email Corresponding Author

Dr. Yi-Ping Hsueh

Institute of Molecular Biology, Academia Sinica

128, Academia Rd., Section 2

Taipei 115, Taiwan (ROC)

Tel. +886 2 278 99311, E-Mail yph@gate.sinica.edu.tw

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CASK-interacting nucleosome assembly protein (CINAP) has been shown to interact with the calcium/calmodulin-dependent serine kinase (CASK) and the T-box transcription factor T-brain-1 (Tbr1) thus modulating the expression of N-methyl-D-aspartic acid receptor subunit 2b (NMDAR2b) in cultured hippocampal neurons. To explore the physiological significance of CINAP in vivo, CINAP knockout mice were generated and subjected to biochemical, anatomical, and behavioral analyses. Unexpectedly, CINAP deletion did not impact NMDAR2b expression, and these CINAP knockout mice were consistently comparable to wild-type littermates in terms of immediate memory (assessed with the Y maze) and associative memory (evaluated by conditioned taste aversion and contextual and auditory fear conditioning). Although CINAP deletion did not obviously influence learning and memory behaviors, CINAP knockout mice exhibited higher locomotor and exploratory activities. Compared with wild-type littermates, the horizontal and vertical movements of the CINAP knockout mice were higher in a novel environment; in home cages, rearing, sniffing, and jumping also occurred more frequently in CINAP knockout mice. These observations suggest that although CINAP deletion in mice does not influence learning and memory behaviors, CINAP is required for restriction of locomotor and exploratory activities.

© 2011 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 17, 2011
Accepted: March 22, 2011
Published online: May 13, 2011
Issue release date: August 2011

Number of Print Pages: 14
Number of Figures: 9
Number of Tables: 0

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

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