For Manuscript Submission, Check or Review Login please go to Submission Websites List.
For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.
Targeted Deletion of CASK-Interacting Nucleosome Assembly Protein Causes Higher Locomotor and Exploratory ActivitiesChung W.-C.a, b · Huang T.-N.b · Hsueh Y.-P.a, b
aGraduate Institute of Life Sciences, National Defense Medical Center, and bInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC Corresponding Author
Dr. Yi-Ping Hsueh
Institute of Molecular Biology, Academia Sinica
128, Academia Rd., Section 2
Taipei 115, Taiwan (ROC)
Tel. +886 2 278 99311, E-Mail firstname.lastname@example.org
CASK-interacting nucleosome assembly protein (CINAP) has been shown to interact with the calcium/calmodulin-dependent serine kinase (CASK) and the T-box transcription factor T-brain-1 (Tbr1) thus modulating the expression of N-methyl-D-aspartic acid receptor subunit 2b (NMDAR2b) in cultured hippocampal neurons. To explore the physiological significance of CINAP in vivo, CINAP knockout mice were generated and subjected to biochemical, anatomical, and behavioral analyses. Unexpectedly, CINAP deletion did not impact NMDAR2b expression, and these CINAP knockout mice were consistently comparable to wild-type littermates in terms of immediate memory (assessed with the Y maze) and associative memory (evaluated by conditioned taste aversion and contextual and auditory fear conditioning). Although CINAP deletion did not obviously influence learning and memory behaviors, CINAP knockout mice exhibited higher locomotor and exploratory activities. Compared with wild-type littermates, the horizontal and vertical movements of the CINAP knockout mice were higher in a novel environment; in home cages, rearing, sniffing, and jumping also occurred more frequently in CINAP knockout mice. These observations suggest that although CINAP deletion in mice does not influence learning and memory behaviors, CINAP is required for restriction of locomotor and exploratory activities.
© 2011 S. Karger AG, Basel