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Vol. 157, No. 3, 2012
Issue release date: February 2012
Section title: Original Paper
Int Arch Allergy Immunol 2012;157:238–245
(DOI:10.1159/000327841)

Walnut Allergy in Peanut-Allergic Patients: Significance of Sequential Epitopes of Walnut Homologous to Linear Epitopes of Ara h 1, 2 and 3 in Relation to Clinical Reactivity

Rosenfeld L.a · Shreffler W.b · Bardina L.b · Niggemann B.a · Wahn U.a · Sampson H.A.b · Beyer K.a
aDepartment of Pediatric Pneumology and Immunology, University Children’s Hospital Charité, Berlin, Germany; bDivision of Pediatric Allergy and Immunology and Jaffe Food Allergy Research Institute, Mount Sinai School of Medicine, New York, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/30/2010
Accepted: 3/25/2011
Published online: 10/27/2011
Issue release date: February 2012

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 2

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: Peanut allergy is a frequent and potentially life-threatening food allergy. Despite the large taxonomic distance between the plants, peanut-allergic patients often react to tree nuts such as walnuts. While the allergens of peanut and walnut have a high degree of homology in their amino-acid sequences, it is unknown whether this similarity is responsible for the observed co-reactivity. Therefore, we analyzed the binding of specific IgE antibodies to sequential epitopes of peanut and walnut in peanut-allergic patients with and without walnut allergy. Methods: The IgE binding to previously described sequential epitopes of peanut and the homologous regions of walnut was assessed in 32 peanut-allergic patients using a peptide microarray technology. Twelve patients had a clinically relevant walnut allergy and 20 were tolerant to walnut. Inhibition assays with peanut peptides and corresponding walnut sequences were performed to show specific binding to sequential epitopes. Results: No differences in the recognition of sequential epitopes could be found between peanut-allergic patients with or without walnut allergy. Only a few patients showed IgE binding to walnut sequences that corresponded to sequential epitopes of peanut. In the inhibition assays, no relevant cross-reacting IgE antibodies could be detected for the peptides analyzed. Conclusion: Our results indicate that although they share a rather high degree of homology with the corresponding regions of walnut allergens, the sequence stretches previously identified as sequential IgE binding epitopes of Ara h 1, Ara h 2 and Ara h 3 have no IgE binding equivalents in walnut allergens.

© 2011 S. Karger AG, Basel


  

Author Contacts

Correspondance to: Prof. Dr. Kirsten Beyer
Department of Pediatric Pneumology and Immunology, University Hospital Charité
Augustenburger Platz 1
DE–13353 Berlin (Germany)
Tel. +49 304 5055 9054, E-Mail kirsten.beyer@charite.de

  

Article Information

Received: September 30, 2010
Accepted after revision: March 25, 2011
Published online: October 27, 2011
Number of Print Pages : 8
Number of Figures : 2, Number of Tables : 2, Number of References : 32
Additional supplementary material is available online - Number of Parts : 1

  

Publication Details

International Archives of Allergy and Immunology

Vol. 157, No. 3, Year 2012 (Cover Date: February 2012)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/30/2010
Accepted: 3/25/2011
Published online: 10/27/2011
Issue release date: February 2012

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 2

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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