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Platelet Recruitment during Multiple Donor Platelet Apheresis Differs between Cell SeparatorsFontana S.a · Keller P.b · Taleghani B.b
a Blood Transfusion Service of the Swiss Red Cross, b Department of Hematology and Central Hematology Laboratory, Division of Transfusion Medicine, Inselspital, University Hospital, Bern, Switzerland Corresponding Author
Dr. Stefano Fontana, Blood Transfusion Service of the Swiss Red Cross, Murtenstrasse 133, 3008 Bern, Switzerland, Tel. +41 31 384-23 23, Fax -23, firstname.lastname@example.org
Background: Recruitment of platelets (PLT) during donor PLT apheresis may facilitate the harvest of multiple units within a single donation. Methods: We compared two PLT apheresis procedures (Amicus and Trima Accel) in a prospective, randomized, paired cross-over study in 60 donors. The 120 donations were compared for depletion of circulating PLT in the donors, PLT yields and PLT recruitment. A recruitment was defined as ratio of total PLT yield and donor PLT depletion > 1. Results: Despite comparable differences of pre- and post-apheresis PLT counts (87 × 109/l in Trima Accel vs. 92 × 109/l in Amicus, p = 0.383), PLT yields were higher with Trima Accel (7.48 × 1011 vs. 6.06 × 1011, p < 0.001), corresponding to a higher PLT recruitment (1.90 vs. 1.42, p < 0.001). We observed a different increase of WBC counts after aphereses, which was more pronounced with Trima Accel than with Amicus (1.30 × 109/l vs. 0.46 × 109/l, p < 0.001). Conclusion: Both procedures induced PLT recruitment. This was higher in Trima Accel, contributing to a higher yield in spite of a comparable depletion of circulating PLT in the donors. This recruitment facilitates the harvest of multiple units within a single donation and seems to be influenced by the procedure utilized. The different increases of circulating donor white blood cells after donation need further investigation.
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