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Table of Contents
Vol. 87, No. 3, 2011
Issue release date: October 2011
Section title: Original Paper
Urol Int 2011;87:319–324
(DOI:10.1159/000328635)

Predicting the Risk of High-Grade Bladder Cancer Using Noninvasive Data

Shapur N. · Pode D. · Katz R. · Shapiro A. · Yutkin V. · Pizov G. · Appelbaum L. · Zorn K.C. · Duvdevani M. · Landau E.H. · Gofrit O.N.
aDepartments of Urology, Pathology and Radiology, Hadassah Hebrew University Hospital, Jerusalem, Israel; bSection of Urology, Department of Surgery, Chicago University of Chicago Medical Center, Chicago, Ill., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/5/2011 10:27:43 AM
Accepted: 4/18/2011
Published online: 8/18/2011

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 4

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Aim: To examine the hypothesis that the risk of high-grade bladder cancer can be predicted using noninvasively obtained data. Patients and Methods: We retrospectively analyzed the database of 431 patients that had transurethral resection of first-time bladder tumors between June 1998 and December 2009. Pre-operative parameters evaluated were: patients’ age; gender; sonographic tumor diameter, number and location of tumor inside the bladder; presence of hydronephrosis, and results of urinary cytology. Parameters that showed significance in multivariate analysis were incorporated into the nomogram. Results: Multivariate analysis of the data showed that patient’s age, the presence of hydronephrosis, sonographic tumor diameter (risk of a high-grade tumor: 14, 29, 43.3, 55.7 and 69.4% at diameters: 0.5–1.5, 1.6–2, 2.1–2.5, 2.6–3 and >3 cm, respectively), location of tumor in the bladder (risk of high-grade tumor: 28.8, 47, 67.5 and 90.5% in the lateral walls, posterior/base, anterior and dome, respectively), and urinary cytology were all highly significant and independent predictors of high-grade tumors. A nomogram constructed using these variables scored an area of 0.853 in the ROC curve. Conclusions: The risk of high-grade bladder tumor can be accurately predicted using non-invasively obtained information. This prediction can help to triage patients with newly detected bladder cancer for biopsy.


  

Author Contacts

Dr. Nandakishore Shapur
Department of Urology, Hadassah University Hospital
PO Box 12000
Jerusalem 91120 (Israel)
Tel. +972 2 677 6874, E-Mail nkgudigar@gmail.com

  

Article Information

Received: January 5, 2011
Accepted after revision: April 18, 2011
Published online: August 18, 2011
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 4, Number of References : 11

  

Publication Details

Urologia Internationalis

Vol. 87, No. 3, Year 2011 (Cover Date: October 2011)

Journal Editor: Wirth M.P. (Dresden), Porena M. (Perugia), Hakenberg O.W. (Rostock), Castro-Diaz D. (Santa Cruz de Tenerife)
ISSN: 0042-1138 (Print), eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/5/2011 10:27:43 AM
Accepted: 4/18/2011
Published online: 8/18/2011

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 4

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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