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Vol. 119, No. 1, 2011
Issue release date: August 2011
Section title: Original Research
Cardiology 2011;119:15–20
(DOI:10.1159/000329048)

The Value of Combining CYP2C19*2 Polymorphism with Classic Risk Factors in Prediction of Clinical Prognosis in Acute Coronary Syndrome Patients

Yan S. · Chen M. · Li Q. · Liu X. · Peng Y. · Chai H. · Xu Y. · Wei J. · Huang D.
aDepartment of Cardiology and bLaboratory of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, PR China

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 1/17/2011 6:43:45 AM
Accepted: 5/3/2011
Published online: 7/16/2011

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Objectives: To assess the impact of different CYP2C19*2 polymorphisms on clinical outcomes and the effects of CYP2C19*2 polymorphism on predicting clinical outcomes in association with classic risk factors in patients with acute coronary syndromes (ACS). Methods: Between July 2008 and September 2009, 497 consecutive patients with ACS who were admitted to the West China Hospital of Sichuan University were enrolled and underwent CYP2C19*2 determination. The clinical outcomes were the composite of cardiovascular death, nonfatal myocardial infarction and nonfatal stroke. Results: Baseline characteristics were balanced between noncarrier, heterozygous and homozygous groups of the CYP2C19*2 variant. The clinical endpoint occurred more frequently in the homozygous group (HR 4.86, CI 1.62–14.56, p = 0.005). After multivariable analysis, the CYP2C19*2 genetic variant was an independent predictor of cardiovascular events (HR 5.96, CI 1.77–20.03, p = 0.0039) as well as GRACE score and Killip class. The combination of CYP2C19*2 with GRACE score and Killip class increases the potential to predict adverse outcomes. Conclusions: Homozygosity (A/A) for CYP2C19*2 mutant is an independent determinant of prognosis in patients with ACS. The combination of CYP2C19*2 polymorphism with classic risk factors may be a useful tool to predict the risk of cardiovascular events.


  

Author Contacts

Mao Chen, PhD, MD, and De-Jia Huang, MD
Department of Cardiology, West China Hospital, Sichuan University
37 Guoxue Street
Chengdu 610041 (PR China)
Tel. +86 28 8542 3362, E-Mail hmaochen@vip.sina.com and huangdjmd@yahoo.com

  

Article Information

Received: January 17, 2011
Accepted after revision: May 3, 2011
Published online: July 16, 2011
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 3, Number of References : 18

  

Publication Details

Cardiology (International Journal of Cardiovascular Medicine, Surgery, Pathology and Pharmacology)

Vol. 119, No. 1, Year 2011 (Cover Date: August 2011)

Journal Editor: Borer J.S. (New York, N.Y.)
ISSN: 0008-6312 (Print), eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 1/17/2011 6:43:45 AM
Accepted: 5/3/2011
Published online: 7/16/2011

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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