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Vol. 37, No. 1, 2011
Issue release date: September 2011
Section title: Original Paper
Neuroepidemiology 2011;37:52–57
(DOI:10.1159/000329258)

Sun Exposure, Vitamin D Intake and Progression to Disability among Veterans with Progressive Multiple Sclerosis

McDowell T.-Y. · Amr S. · Culpepper W.J. · Langenberg P. · Royal W. · Bever C. · Bradham D.D.
aMS Center of Excellence–East, Baltimore VAMC, Departments of bEpidemiology and Public Health and cNeurology, University of Maryland, Baltimore School of Medicine, and dDepartment of Pharmaceutical Health Services Research, University of Maryland, Baltimore School of Pharmacy, Baltimore, Md., and eDepartment of Preventive Medicine and Public Health, University of Kansas, School of Medicine–Wichita, Wichita, Kans., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/13/2010
Accepted: 5/11/2011
Published online: 8/5/2011

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

Abstract

Background: Early life events have been suggested to influence multiple sclerosis (MS) susceptibility, and to potentially modulate its clinical course. We assessed vitamin D-related exposures from childhood to disease onset and their associations with MS progression. Methods: Among veterans in the Multiple Sclerosis Surveillance Registry, 219 reported having the progressive form and met the inclusion criteria. Participants reported their past sun exposure, vitamin D-related intake and age at disability milestones using the Patient-Determined Disease Steps (PDDS). The Cox proportional hazards model was used to examine the association between vitamin D-related exposures and time (years) to disability. Results: Low average sun exposure in the fall/winter before disease onset was associated with an increased risk of progressing to a PDDS score of 8 (hazard ratio, HR: 2.13, 95% confidence interval, CI: 1.20–3.78), whereas use of cod liver oil during childhood and adolescence was associated with a reduced risk (HR: 0.44, 95% CI: 0.20–0.96). Conclusions: These results suggest that exposure to vitamin D before MS onset might slow disease-related neurodegeneration and thus delay progression to disability among patients with the progressive subtype.


  

Author Contacts

Tzu-Yun McDowell
Tel. +1 301 802 7910
E-Mail tycmcdowell@hotmail.com

  

Article Information

Received: December 13, 2010
Accepted: May 11, 2011
Published online: August 5, 2011
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 2, Number of References : 30

  

Publication Details

Neuroepidemiology

Vol. 37, No. 1, Year 2011 (Cover Date: September 2011)

Journal Editor: Feigin V.L. (Auckland)
ISSN: 0251-5350 (Print), eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/13/2010
Accepted: 5/11/2011
Published online: 8/5/2011

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


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