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Vol. 6, No. 3, 2011
Issue release date: June 2011
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Breast Care 2011;6:179–183
Review Article · Übersichtsarbeit

Adjuvant Systemic Therapy of Breast Cancer

Schuetz F.
Department of Gynecology and Obstetrics, Heidelberg University Hospital, Germany Breast Care 2011;6:179–183 (DOI:10.1159/000329336)


The first procedure in primary breast cancer is usually the surgical excision of the tumor. However, a medical therapy is necessary in almost all patients to treat the systemic component of the disease. Which medical approach is recommended depends on the biology of the tumor itself. Endocrine-responsive tumors must be treated by an endocrine therapy according to their menopausal status. In HER2/neu-overexpressing tumors, the monoclonal antibody trastuzumab is part of the standard treatment in combination with chemotherapy. Hormone receptor-negative and non-HER2/neu-overexpressing tumors as well as endocrine-responsive tumors with a high proliferation index or additional risk factors must be treated with chemotherapy as well. This review article gives further information about the available agents and schedules.

 goto top of outline Author Contacts

PD Dr. med. Florian Schütz, Universitätsfrauenklinik Heidelberg, Voßstr. 9, 69115 Heidelberg, Germany, Tel. +49 6221 56-37688, Fax -5712,

 goto top of outline Article Information

Published online June 3, 2011
Number of Print Pages : 5

 goto top of outline Publication Details

Breast Care (Multidisciplinary Journal for Research, Diagnosis and Therapy)

Vol. 6, No. 3, Year 2011 (Cover Date: June 2011)

Journal Editor: Harbeck N. (Köln), Thomssen C. (Halle/Saale), Gnant M. (Wien)
ISSN: 1661-3791 (Print), eISSN: 1661-3805 (Online)

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