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Vol. 34, No. 3, 2011
Issue release date: September 2011
Am J Nephrol 2011;34:203–210

C-Reactive Protein and the Risk of Contrast-Induced Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention

Gao F. · Zhou Y.J. · Zhu X. · Wang Z.J. · Yang S.W. · Shen H.
Department of Cardiology, An Zhen Hospital, Capital Medical University, Beijing, China

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Background: The relationship between preprocedural C-reactive protein (CRP) levels and the incidence of contrast-induced acute kidney injury (CI-AKI) is unknown. Methods: Documents of 7,310 consecutive patients undergoing percutaneous coronary intervention (PCI) were screened. Patients with acute myocardial infarction, cardiogenic shock, concomitant inflammatory conditions or undergoing CABG within 48 h were excluded due to potential confounding effects. Results: A total of 4,522 patients were valid for analysis. The median follow-up was 26 months (interquartile range 20–33 months). According to preprocedural CRP values, patients were divided into 3 groups: group 1: CRP <1.0 mg/l (n = 1,523); group 2: 1.0 mg/l ≤ CRP ≤ 3.0 mg/l (n = 1,626); group 3: CRP >3.0 mg/l (n = 1,373). Patients with higher preprocedural CRP levels were associated with a significantly increased rate of CI-AKI (10.6 vs. 14.9 vs. 23.5%, p < 0.0001). After adjustment for baseline covariates, CRP level was still an independent predictor for the incidence of CI-AKI, either as a continuous variable or a categorical variable. Patients with higher CRP values had a significantly higher rate of all-cause mortality and myocardial infarction during follow-up. Conclusion: Elevated preprocedural CRP is associated with an increased risk for CI-AKI in patients undergoing PCI. Preprocedural risk stratification with CRP as an adjunct to established clinical risk factors might be useful.

 goto top of outline Author Contacts

Yu Jie Zhou, MD
Department of Cardiology, An Zhen Hospital, Capital Medical University
Anzhenli avenue, Chao Yang District
Beijing 100029 (China)
Tel. +86 10 64 456 028, E-Mail

 goto top of outline Article Information

Received: March 14, 2011
Accepted: May 19, 2011
Published online: July 23, 2011
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 4, Number of References : 30

 goto top of outline Publication Details

American Journal of Nephrology

Vol. 34, No. 3, Year 2011 (Cover Date: September 2011)

Journal Editor: Bakris G. (Chicago, Ill.)
ISSN: 0250-8095 (Print), eISSN: 1421-9670 (Online)

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