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Vol. 73, No. 4, 2011
Issue release date: August 2011
Section title: Original Paper
ORL 2011;73:219–228
(DOI:10.1159/000329791)

Protection of Inner Ear Function after Cochlear Implantation: Compound Action Potential Measurements after Local Application of Glucocorticoids in the Guinea Pig Cochlea

Braun S.a, b, e · Ye Q.f · Radeloff A.c · Kiefer J.d · Gstoettner W.a · Tillein J.a, g
Departments of aSensory Physiology II and bENT, J.W. Goethe University, Frankfurt am Main, cDepartment of ENT, Julius Maximilian University Wuerzburg, Wuerzburg, and dDepartment of ENT, Klinikum rechts der Isar, Technical University Munich, and eMED-EL Deutschland GmbH, Munich, Germany; fDepartment of Otolaryngology, Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China; gMED-EL Innsbruck, Innsbruck, Austria

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/8/2011
Accepted: 5/24/2011
Published online: 7/21/2011
Issue release date: August 2011

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 1

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL

Abstract

Background: Cochlear implant users with residual hearing often benefit greatly from simultaneous electric and acoustic stimulation. However, implantation can cause trauma to the inner ear, resulting in poorer hearing postoperatively. We investigated whether a single local injection of glucocorticoids can reduce hearing loss in long-term implanted guinea pigs. Methods: Three groups of animals underwent bilateral surgery. One ear was implanted with an electrode, and the contralateral ear received a cochleostomy only. A single dose of the glucocorticoids triamcinolone or dexamethasone, or of artificial perilymph was infused into cochleae via cochleostomy. Compound action potentials were measured before and after application and for 3 months postoperatively. Tissue growth was measured as the percentage of the total area of the scala tympani that was obliterated. Results: Ears subjected to cochleostomy only and treated with glucocorticoids demonstrated a mild hearing loss. In the implanted ears, both glucocorticoids preserved hearing at least temporarily. The volume of tissue growth within the scala tympani was not reduced, and there was no relation between the amount of tissue and hearing loss. Conclusions: Both glucocorticoids show a potential benefit for hearing preservation in implanted ears. Glucocorticoid therapy may be useful to protect residual hearing during cochlear implantation.

© 2011 S. Karger AG, Basel


  

Author Contacts

Dr. rer. nat. Susanne Braun
Zentrum für HNO, Physiologie/Audiologische Akustik
Universitätsklinikum der J.W.-Goethe-Universität
Theodor-Stern-Kai 7, DE–60590 Frankfurt am Main (Germany)
Tel. +49 69 6301 6728, E-Mail s.braun@med.uni-frankfurt.de

  

Article Information

Received: March 8, 2011
Accepted after revision: May 24, 2011
Published online: July 21, 2011
Number of Print Pages : 10
Number of Figures : 3, Number of Tables : 1, Number of References : 28

  

Publication Details

ORL (Journal for Oto-Rhino-Laryngology, Head and Neck Surgery)

Vol. 73, No. 4, Year 2011 (Cover Date: August 2011)

Journal Editor: O'Malley Jr. B.W. (Philadelphia, Pa.)
ISSN: 0301-1569 (Print), eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/8/2011
Accepted: 5/24/2011
Published online: 7/21/2011
Issue release date: August 2011

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 1

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL


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