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Vol. 3, No. 2, 2011
Issue release date: May – August
Open Access Gateway
Case Rep Dermatol 2011;3:170–174
(DOI:10.1159/000330460)
Published: August 2011

A Case of Angioleiomyoma with Epithelioid Granuloma

Onishi M. · Takahashi K. · Watabe D. · Onodera H. · Akasaka T.
Department of Dermatology, Iwate Medical University, Morioka, Japan

Abstract

We describe a 61-year-old Japanese woman who had been aware of a lesion on her left thigh for 10 years. Pathological examination demonstrated a well-circumscribed encapsulated nodule at the dermal-subcutaneous boundary, composed of eosinophilic spindle cell bundles, connective tissue, and numerous small vessels. Immunohistochemically, these eosinophilic cells were positive for α-smooth muscle actin. The granulomatous areas in the tumor were composed focally of epithelioid cells and lymphocytes. The epithelioid cells were negative for α-smooth muscle actin. We diagnosed this case as an angioleiomyoma with epithelioid granuloma. Malignant tumors with granulomatous change have sometimes been reported in the literature, but benign tumors with epithelioid granuloma, such as the present one, are rare. We thought that epithelioid cell granuloma might transform to angioleiomyoma through the action of IL-1 released from vascular smooth muscle cells.

 goto top of outline Author Contacts

Masazumi Onishi
Department of DermatologyIwate Medical University
19-1 Uchimaru, Morioka 020-8505 (Japan)
E-Mail monishi@iwate-med.ac.jp


 goto top of outline Article Information

Published online: August 25, 2011
Number of Print Pages : 5
Number of Figures : 3, Number of Tables : 1,


 goto top of outline Publication Details

Case Reports in Dermatology

Vol. 3, No. 2, Year 2011 (Cover Date: May - August)

Journal Editor: Jemec G.B.E. (Roskilde)
ISSN: NIL (Print), eISSN: 1662-6567 (Online)

For additional information: http://www.karger.com/CDE


Open Access License / Drug Dosage

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