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Table of Contents
Vol. 45, No. 5, 2011
Issue release date: November 2011
Section title: Original Paper
Caries Res 2011;45:486–493
(DOI:10.1159/000330604)

Fluoride Intake of Japanese Infants from Infant Milk Formula

Nohno K.a · Zohoori F.V.b · Maguire A.c
aDivision of Preventive Dentistry, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Japan; bSchool of Health and Social Care, Teesside University, Middlesbrough, and cSchool of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 11, 2011
Accepted: June 28, 2011
Published online: September 09, 2011
Issue release date: November 2011

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE

Abstract

This study aimed to measure the fluoride (F) content of all infant milk formulas (IMF) available for purchase in Japan and estimate the F exposure of infants whose primary source of nutrition is IMF when reconstituted with different F concentrations of water. Twenty-two commercially available IMFs were purchased from 6 manufacturers in Japan. These IMFs included 21 milk-based products and 1 soy-based product. Each IMF was reconstituted using distilled water and 0.13 µg F/ml fluoridated water according to the manufacturers’ instructions. The F concentrations in each sample were measured using the hexamethyldisiloxane diffusion technique and an F ion-selective electrode. The mean F concentration of all products was 0.41 (range 0.15–1.24) µg/g. There were no statistically significant differences among mean F concentrations of newborn milks, follow-on milks and other milks or among manufacturers. The mean F concentration of all products, when reconstituted with distilled water and 0.13 µg F/ml water, was 0.09 and 0.18 µg/ml, respectively. The mean F intake from IMF ranged from 0.039 to 0.134 mg/day with distilled water and from 0.078 to 0.258 mg/day with 0.13 µg/ml fluoridated water, respectively. These results suggested that F intake of infants from IMFs depended on the F concentration of added water, and therefore the risk of dental fluorosis for most Japanese infants would be small since most Japanese municipal water supplies are low in F. However, there was a possibility to exceed the tolerable upper intake level, even under the limit of the law, especially for infants within the first 5 months of life.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 11, 2011
Accepted: June 28, 2011
Published online: September 09, 2011
Issue release date: November 2011

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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