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Vol. 158, No. 1, 2012
Issue release date: April 2012
Section title: Original Paper
Int Arch Allergy Immunol 2012;158:71–76
(DOI:10.1159/000330661)

Clinical Utility of IgE Antibodies to ω-5 Gliadin in the Diagnosis of Wheat Allergy: A Pediatric Multicenter Challenge Study

Ebisawa M.a · Shibata R.b · Sato S.a · Borres M.P.d, e · Ito K.c
aClinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, bDepartment of Pediatrics, Fukuoka National Hospital, Fukuoka, and cDepartment of Allergy, Aichi Children‘s Health and Medical Center, Obu, Japan; dMedical Department, Phadia AB, Uppsala, and eInstitute for Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/3/2011 11:14:26 AM
Accepted: 6/30/2011
Published online: 12/29/2011
Issue release date: April 2012

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: There are contradictory results regarding the clinical usefulness of the determination of IgE antibodies to ω-5 gliadin in children with a suspicion of wheat allergy (WA). Methods: The study comprised 311 children and young adults with suspected wheat intolerance treated at three separate pediatric clinics and, with the exception of 25, were found to be positive in specific IgE antibody determinations to wheat. Their ages ranged from 6 months to 20.4 years (median age, 2.3 years). Possible relationships between IgE antibodies to ω-5 gliadin and a physician’s diagnosis of WA and challenge symptoms were studied. Results: The mean concentration of IgE antibodies to ω-5 gliadin was 1.2 kUA/l in WA patients and <0.35 kUA/l in patients without WA (p < 0.0001). Seventy-two percent of the WA patients had positive ω-5 gliadin levels and 75% of the patients without WA had negative levels. Logistic regression showed a significant relationship between the probability of WA and the concentration of IgE antibodies to ω-5-gliadin with a 2.6-fold (95% CI: 2.0–3.3) increased risk. Age was an important factor to consider as the risk of WA increased 5.4-fold (95% CI: 1.4–21) for children ≤1 year of age and 2.5-fold (95% CI: 2.0–3.2) for children >1 year of age with increasing levels of IgE. Conclusion: Detection of IgE to ω-5 gliadin seems to be associated with responsiveness to the challenge test and is particularly useful in infants with a suspicion of WA.


  

Author Contacts

Correspondence to: Dr. Motohiro Ebisawa
Clinical Research Center for Allergy and Rheumatology
Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku
Sagamihara, Kanagawa 252-0392 (Japan)
Tel. +81 42 742 8311, E-Mail m-ebisawa@sagamihara-hosp.gr.jp

  

Article Information

Received: March 3, 2011
Accepted after revision: June 30, 2011
Published online: December 29, 2011
Number of Print Pages : 6
Number of Figures : 4, Number of Tables : 1, Number of References : 13

  

Publication Details

International Archives of Allergy and Immunology

Vol. 158, No. 1, Year 2012 (Cover Date: April 2012)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/3/2011 11:14:26 AM
Accepted: 6/30/2011
Published online: 12/29/2011
Issue release date: April 2012

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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