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Vol. 127, No. 1, 2012
Issue release date: December 2011
Section title: Case Report
Acta Haematol 2012;127:20–22
(DOI:10.1159/000330951)

Efficacy of Low-Dose Rituximab in a Refractory Acquired Factor VIII Inhibitor Case Secondary to Pemphigus

Gao Y. · Liu S. · Ma G. · Lv L. · Su Y.
Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, China

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 4/7/2011 9:30:38 AM
Accepted: 7/18/2011
Published online: 10/12/2011

Number of Print Pages: 3
Number of Figures: 1
Number of Tables: 1

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

Acquired factor VIII (FVIII) inhibitor induces a bleeding disorder caused by specific antibodies to FVIII. The cause of approximately one fifth of cases can be attributed to autoimmune disorders, such as pemphigus. Here, we describe a case of refractory acquired FVIII inhibitor in a patient with primary pemphigus and its successful treatment with low-dose rituximab. Coagulation studies revealed a prolonged activated partial thromboplastin time, which could not be corrected with the mixing test. At the same time, the FVIII activity level was significantly reduced, and the FVIII inhibitor titer was elevated. A treatment regimen with prednisolone/cyclophosphamide followed by prednisolone/cyclosporine was used. The patient temporarily responded but then became resistant to these medicines. However, subsequent treatment with low-dose rituximab achieved considerable clinical and laboratory improvement in the same patient. Follow-up at 6 months revealed a low level of residual FVIII inhibitor activity with normal coagulation functions. No drug-related side effects were detected. In conclusion, our results indicate that low-dose rituximab might be an effective and safe treatment for patients with acquired FVIII inhibitor.


  

Author Contacts

Yanhua Su
Department of Hematology, The First Affiliated Hospital
Harbin Medical University, 23 Youzheng Street
Harbin 150001 (China)
Tel. +86 451 8555 5961, E-Mail suyanhua163@163.com

  

Article Information

Received: April 7, 2011
Accepted after revision: July 18, 2011
Published online: October 12, 2011
Number of Print Pages : 3
Number of Figures : 1, Number of Tables : 1, Number of References : 18

  

Publication Details

Acta Haematologica

Vol. 127, No. 1, Year 2012 (Cover Date: December 2011)

Journal Editor: Ben-Bassat I. (Qiryat-Ono)
ISSN: 0001-5792 (Print), eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 4/7/2011 9:30:38 AM
Accepted: 7/18/2011
Published online: 10/12/2011

Number of Print Pages: 3
Number of Figures: 1
Number of Tables: 1

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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