Cover

Current and Future Management of Brain Metastasis

Editor(s): Kim D.G. (Seoul) 
Lunsford L.D. (Pittsburgh, Pa.) 
Table of Contents
Vol. 25, 2012
Section title: General Management
Kim DG, Lunsford LD (eds): Current and Future Management of Brain Metastasis. Prog Neurol Surg. Basel, Karger, 2012, vol 25, pp 82–95
(DOI:10.1159/000331179)

Whole-Brain Radiation Therapy of Brain Metastasis

Sahgal A. · Soliman H. · Larson D.A.
aDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Princess Margaret Hospital and bDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont., Canada; cDepartment of Radiation Oncology, University of California San Francisco, San Francisco, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of General Management

Published online: 1/6/2012
Cover Date: 2012

Number of Print Pages: 14
Number of Figures: 2
Number of Tables: 0

ISBN: 978-3-8055-9617-6 (Print)
eISBN: 978-3-8055-9618-3 (Online)

Abstract

The purpose of this report was to review the role of whole brain radiotherapy (WBRT) in the management of brain metastases. In particular, we review the role of WBRT as a prophylactic therapy, and the role of surgery and stereotactic radiousurgery (SRS) with respect to WBRT, by discussing the relevant randomized controlled trials. WBRT is associated with toxicities and this may influence the decision to use WBRT and, therefore, we review both the acute side effects of WBRT and the moreserious late side effects of neurocognitive impairment and leukoencephalopathy. As patients are living longer with brain metastases the role of WBRT is moving forward; however, using modern radiation technology we may be able to reduce the morbidity of this therapy. We present an extreme case of re-re-treatment WBRT with hippocampal sparing and simultaneous integrated boosts to multiple lesions as one of the future directions under evaluation.


  

Author Contacts

Arjun Sahgal, MD, Department of Radiation Oncology, University of Toronto, 610 University Avenue, Toronto, ON M5G 2M9 (Canada), Tel. +1 416 946 2131, E-Mail Arjun.sahgal@rmp.uhn.on.ca

  

Article Information

Published online: January 06, 2012
Number of Print Pages : 14

  

Publication Details

Book Serie: Progress in Neurological Surgery, Vol. 25, Year 2012

Editor(s): Lunsford, L.D. (Pittsburgh, Pa
ISSN: 0079-6492 (Print), eISSN: 1662-3924 (Online)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=0079-6492

Book Title: Current and Future Management of Brain Metastasis

Editor(s): Kim DG, Lunsford LD (eds)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=0079-6492&volume=25


Article / Publication Details

First-Page Preview
Abstract of General Management

Published online: 1/6/2012
Cover Date: 2012

Number of Print Pages: 14
Number of Figures: 2
Number of Tables: 0

ISBN: 978-3-8055-9617-6 (Print)
eISBN: 978-3-8055-9618-3 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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