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Vol. 6, No. 1-3, 2012
Issue release date: February 2012
Section title: Paper
Sex Dev 2012;6:143-150
(DOI:10.1159/000331477)

Y-Autosome Translocation Interferes with Meiotic Sex Inactivation and Expression of Autosomal Genes: A Case Study in the Pig

Barasc H.a, b · Mary N.a, b · Letron R.c · Calgaro A.a, b · Dudez A.M.a, b · Bonnet N.a, b · Lahbib-Mansais Y.a, b · Yerle M.a, b · Ducos A.a, b · Pinton A.a, b
aLaboratoire de Génétique Cellulaire, UMR 444, Institut National de la Recherche Agronomique (INRA), bGénétique Cellulaire, UMR 444, ENVT, INP, Université de Toulouse, and cLaboratoire d'Histopathologie, Département des Sciences Biologiques et Fonctionnelles, Toulouse, France

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 9/13/2011
Issue release date: February 2012

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 0

ISSN: 1661-5425 (Print)
eISSN: 1661-5433 (Online)

For additional information: http://www.karger.com/SXD

Abstract

Y-autosome translocations are rare in humans and pigs. In both species, these rearrangements can be responsible for meiotic arrest and subsequent infertility. Chromosome pairing abnormalities on the SSCX, SSCY and SSC1 chromatin domains were identified by analyzing pachytene spermatocytes from a boar carrying a (Y;1) translocation by immunolocalization of specific meiotic protein combined with FISH. Disturbance of the meiotic sex chromosome inactivation (MSCI) was observed by Cot-RNA-FISH and analysis of ZFY gene expression by sequential RNA- and DNA-FISH on spermatocytes. We hypothesized that the meiotic arrest observed in this boar might be due to the silencing of critical autosomal genes and/or the reactivation of some sex chromosome genes.


  

Author Contacts

Alain Pinton
UMR 444 INRA-ENVT Génétique Cellulaire, ENVT BP 87614
23 Chemin des Capelles
FR-31076 Toulouse Cedex 3 (France)
Tel. +33 561 193 923, E-Mail a.pinton@envt.fr

  

Article Information

Published online: September 13, 2011
Number of Print Pages : 8
Number of Figures : 5, Number of Tables : 0, Number of References : 26

  

Publication Details

Sexual Development (Genetics, Molecular Biology, Evolut on, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation)

Vol. 6, No. 1-3, Year 2012 (Cover Date: February 2012)

Journal Editor: Schmid M. (Würzburg), Scherer G. (Freiburg), Schartl M. (Würzburg)
ISSN: 1661-5425 (Print), eISSN: 1661-5433 (Online)

For additional information: http://www.karger.com/SXD


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 9/13/2011
Issue release date: February 2012

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 0

ISSN: 1661-5425 (Print)
eISSN: 1661-5433 (Online)

For additional information: http://www.karger.com/SXD


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