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Table of Contents
Vol. 37, No. 2, 2011
Issue release date: October 2011
Section title: Methods in Neuroepidemiology
Free Access
Neuroepidemiology 2011;37:129–140

Validation of a Research Case Definition of Gulf War Illness in the 1991 US Military Population

Iannacchione V.G.a · Dever J.A.a · Bann C.M.a · Considine K.A.a · Creel D.a · Carson C.P.a · Best H.a · Haley R.W.b
aRTI International, Research Triangle Park, N.C., and bDivision of Epidemiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Tex., USA
email Corresponding Author

Prof. Robert W. Haley, MD

Division of Epidemiology, Department of Internal Medicine

University of Texas Southwestern Medical Center

5323 Harry Hines Blvd, Dallas, TX 75390-8874 (USA)

Tel. +1 214 648 3075, E-Mail Robert.Haley@UTSouthwestern.edu

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Background: A case definition of Gulf War illness with 3 primary variants, previously developed by factor analysis of symptoms in a US Navy construction battalion and validated in clinic veterans, identified ill veterans with objective abnormalities of brain function. This study tests prestated hypotheses of its external validity. Methods: A stratified probability sample (n = 8,020), selected from a sampling frame of the 3.5 million Gulf War era US military veterans, completed a computer-assisted telephone interview survey. Application of the prior factor weights to the subjects’ responses generated the case definition. Results: The structural equation model of the case definition fit both random halves of the population sample well (root mean-square error of approximation = 0.015). The overall case definition was 3.87 times (95% confidence interval, 2.61–5.74) more prevalent in the deployed than the deployable nondeployed veterans: 3.33 (1.10–10.10) for syndrome variant 1; 5.11 (2.43–10.75) for variant 2, and 4.25 (2.33–7.74) for variant 3. Functional status on SF-12 was greatly reduced (effect sizes, 1.0–2.0) in veterans meeting the overall and variant case definitions. Conclusions: The factor case definition applies to the full Gulf War veteran population and has good characteristics for research.

© 2011 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Methods in Neuroepidemiology

Received: June 07, 2011
Accepted: August 03, 2011
Published online: October 07, 2011
Issue release date: October 2011

Number of Print Pages: 12
Number of Figures: 3
Number of Tables: 5

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

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