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Table of Contents
Vol. 73, No. 3, 2012
Issue release date: April 2012
Section title: Original Article
Gynecol Obstet Invest 2012;73:183–188
(DOI:10.1159/000331648)

Thrombophilia among Chinese Women with Venous Thromboembolism during Pregnancy

Tam W.-H.a · Ng M.H.-L.b · Yiu A.K.-W.a · Lau K.-M.b · Cheng G.Y.-M.c · Li C.-Y.a
Departments of aObstetrics and Gynecology, bAnatomical and Cellular Pathology, and cMedicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, SAR, China

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: December 23, 2010
Accepted: July 13, 2011
Published online: March 06, 2012
Issue release date: April 2012

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Aims: To assess the prevalence of thrombophilia among Chinese women with venous thromboembolism (VTE) developed during pregnancy. Methods: Based on information from a tertiary teaching unit, all recorded cases of deep vein thrombosis (DVT) and pulmonary embolism (PE) during pregnancy diagnosed between 1997 and 2005, were assessed for prevalence of thrombophilia. Fifty-five healthy women, who had at least one normal pregnancy but without any previous history of VTE, were recruited as controls. Results: A total of 44 subjects completed thrombophilia screening, of whom 5 (11%) were confirmed to have thrombophilia [protein C (PC) deficiency (2), protein S (PS) deficiency (1), combined PC & PS deficiency (1) and antithrombin III deficiency (1)]. Homozygous 5,10-methylenetetrahydrofolate reductase (C677T) gene mutation was found in 6 (14%) subjects but not in the controls. There was no antiphospholipid syndrome, activated PC resistance, factor V Leiden or prothrombin gene mutations. Conclusion: In the Chinese population, PS and PC deficiencies are common thrombophilia for VTE during pregnancy and thrombophilia screening should be recommended in all pregnant women who suffer from VTE.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: December 23, 2010
Accepted: July 13, 2011
Published online: March 06, 2012
Issue release date: April 2012

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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