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Table of Contents
Vol. 58, No. 2, 2012
Issue release date: February 2012
Section title: Clinical Section / Debate
Gerontology 2012;58:120–122
(DOI:10.1159/000331798)

The Fate of Fat

Belaj K.J.a · Eller P.a, b
aDivision of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, and bDepartment for Clinical Medicine and Biotechnology, Center of Management and Healthcare, Danube University Krems, Krems, Austria

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Article / Publication Details

First-Page Preview
Abstract of Clinical Section / Debate

Received: 7/25/2011 2:39:07 PM
Accepted: 8/4/2011
Published online: 12/17/2011
Issue release date: February 2012

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER

Abstract

Adipose tissue is not merely a storage depot for fat. Both brown and white adipose tissues are finely regulated endocrine organs that modulate energy balance and temperature homeostasis. In a recent issue of Gerontology, Saely and Drexel dissected the different morphology and the prime functions of brown and white adipose tissue. They impressively showed that adipose tissues are not inert deposits, but instead highly plastic tissues in close interface with guts, liver, and brain. Brown and white adipose tissues are essentially complementary organs that serve different teleological purposes. The molecular understanding of their physiological pathways opens the door to the development of a rational pharmacotherapy of obesity and associated disorders. Thus, the targeting of energy expenditure in brown adipose tissue may be an attractive alternative strategy to combat obesity. However, every intervention in cellular bioenergetics to treat obesity or cachexia will have to face principal safety considerations, as the thermodynamic implications of such interventions are largely unknown and potentially dangerous.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Section / Debate

Received: 7/25/2011 2:39:07 PM
Accepted: 8/4/2011
Published online: 12/17/2011
Issue release date: February 2012

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER


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