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Table of Contents
Vol. 223, No. 3, 2011
Issue release date: December 2011
Section title: Case Report
Dermatology 2011;223:207–210
(DOI:10.1159/000331810)

Involvement of Brown Adipose Tissue in Subcutaneous Fat Necrosis of the Newborn

Ichimiya H.a · Arakawa S.a · Sato T.a · Shimada T.b · Chiba M.c · Soma Y.f · Mizoguchi M.f · Tomonari K.g · Iwasaka H.d · Hatano Y.e · Okamoto O.e · Fujiwara S.e
aDepartment of Dermatology, Oita Prefectural Hospital, Oita, bDepartment of Fundamental Nursing, cDepartment of Internal Medicine 1, dDepartment of Anesthesiology and Intensive Care, eDepartment of Dermatology, Faculty of Medicine, Oita University, Yufu, fDepartment of Dermatology, St. Marianna University, School of Medicine, Kawasaki, and gOita Diagnostic Imaging Center, Beppu, Japan

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 5/23/2011 9:42:09 AM
Accepted: 7/30/2011
Published online: 9/28/2011
Issue release date: December 2011

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: Subcutaneous fat necrosis (SCFN) of the newborn is a rare condition that manifests within days after birth. The interscapular region, axillae and shoulders are the most commonly affected sites, corresponding to anatomic sites of brown adipose tissue (BAT) in newborns. Objective: We postulated a specific involvement of BAT in SCFN and searched for brown adipocytes at affected sites. Methods: Biopsy specimens were immunostained with antibodies against uncoupling protein 1 (UCP-1) and examined by electron microscopy. We also examined BAT by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography and computed tomography (PET-CT) scanning. Results: A few cells in biopsy specimens from two patients bound antibodies against UCP-1, and brown adipocytes were detected at several stages of degeneration. PET-CT scans revealed lower uptake of 18F-FDG at major sites of SCFN. Conclusion: SCFN and BAT can be found at the same sites, suggesting a pathophysiological connection.

© 2011 S. Karger AG, Basel


  

Author Contacts

Sakuhei Fujiwara
Department of Dermatology, Faculty of Medicine, Oita University
Idaigaoka 1-1, Hasama-machi
Yufu City 879-5593 (Japan)
Tel. +81 97 586 5880, E-Mail fujiwara@oita-u.ac.jp

  

Article Information

Received: May 23, 2011
Accepted after revision: July 30, 2011
Published online: September 28, 2011
Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 1, Number of References : 19

  

Publication Details

Dermatology

Vol. 223, No. 3, Year 2011 (Cover Date: December 2011)

Journal Editor: Saurat J.-H. (Geneva)
ISSN: 1018-8665 (Print), eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 5/23/2011 9:42:09 AM
Accepted: 7/30/2011
Published online: 9/28/2011
Issue release date: December 2011

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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