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Cover

New Trends in Allergy and Atopic Eczema

Editor(s): Ring J. (Munich) 
Darsow U. (Munich) 
Behrendt H. (Munich) 
Table of Contents
Vol. 96, 2012
Section title: Pathogenesis of the Deviated Immune Response
Ring J, Darsow U, Behrendt H (eds): New Trends in Allergy and Atopic Eczema. Chem Immunol Allergy. Basel, Karger, 2012, vol 96, pp 61–72
(DOI:10.1159/000331884)

What Can Dogs Bring to Atopic Dermatitis Research?

Olivry T.
Department of Clinical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, N.C., USA

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Article / Publication Details

First-Page Preview
Abstract of Pathogenesis of the Deviated Immune Response

Published online: March 13, 2012
Cover Date: 2012

Number of Print Pages: 12
Number of Figures: 1
Number of Tables: 0

ISBN: 978-3-8055-9894-1 (Print)
eISBN: 978-3-8055-9895-8 (Online)

Abstract

Besides humans, dogs are the only animals that naturally develop skin lesions of atopic dermatitis (AD). In the last two decades, numerous studies have helped establish the close similarity between human and canine AD at the pathogenesis, clinical, epidemiological and therapeutic levels. The study of dogs with AD could potentially be very useful to human AD research because of the species’ historical inbred selection that would permit breed-specific genetic, epidemiological or mechanistic studies. Clinical trials enrolling privately owned dogs are helpful for testing the validity of novel preventive or therapeutic interventions before these are used in human patients. Finally, skin lesions of AD can be provoked via environmental, systemic or epicutaneous allergen challenges in dogs that are spontaneously or experimentally sensitized to common dietary or environmental allergens. These experimental canine AD models have proven their utility to test the efficacy of novel treatment modalities in a preclinical setting. In conclusion, natural or experimental canine AD can provide researchers with a unique model to investigate genetic, epidemiological, mechanistic or treatment facets of the human disease. Due to the unique similarity of the disease in both species, the obtained information would very likely be translatable to human patients.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Pathogenesis of the Deviated Immune Response

Published online: March 13, 2012
Cover Date: 2012

Number of Print Pages: 12
Number of Figures: 1
Number of Tables: 0

ISBN: 978-3-8055-9894-1 (Print)
eISBN: 978-3-8055-9895-8 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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