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Table of Contents
Vol. 47, No. 4, 2012
Issue release date: April 2012
Section title: Original Paper
Ophthalmic Res 2012;47:195–201
(DOI:10.1159/000331992)

Altered MicroRNA Expression Profiles in Retinas with Diabetic Retinopathy

Wu J.a · Gao Y.a, b · Ren A.c · Zhao S.a · Zhong M.a · Peng Y.a · Shen W.a · Jing M.b · Liu L.a
Departments of Ophthalmology ataChanghai Hospital and bNo. 411 Hospital of CPLA, cDepartment of Pathophysiology, Second Military Medical University, Shanghai, China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 04, 2011
Accepted: August 05, 2011
Published online: December 08, 2011
Issue release date: April 2012

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: http://www.karger.com/ORE

Abstract

Rats with streptozotocin (STZ)-induced diabetes were studied in order to identify abnormal microRNA (miRNA) expression profiles in diabetic retinopathy (DR) and to ascertain miRNAs associated with DR. Histopathologically, we observed characteristic features of DR in rats at 10 weeks after STZ injection. Investigation of miRNA expression profiles in the retinas of control and diabetic rats using miRNA microarrays revealed that many miRNAs were abnormally expressed in DR. On the basis of their fold changes and probability values, a total of 37 miRNAs were selected for further validation by real-time PCR analysis. The results showed that 11 miRNAs were significantly upregulated and 6 miRNAs were notably downregulated in DR. Furthermore, these changes in retinal miRNA expression levels paralleled the course of DR. Levels of miR-182, miR-96, miR-183, miR-211, miR-204, and miR-124 were significantly increased during the progress of DR, whereas miR-10b, miR-10a, miR-219-2-3p, miR-144, miR-338, and miR-199a-3p were significantly decreased. Our data indicate that the aberrant miRNA expression profiles in DR are associated with the development of DR. Modulation of retinal miRNA expression levels may provide a potential therapeutic strategy for DRs.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 04, 2011
Accepted: August 05, 2011
Published online: December 08, 2011
Issue release date: April 2012

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: http://www.karger.com/ORE


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