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Vol. 56, No. 2, 2012
Issue release date: March–April
Section title: Novel Insights from Clinical Practice
Acta Cytologica 2012;56:204–208
(DOI:10.1159/000332365)

Blastic Plasmacytoid Dendritic Cell Neoplasm: Cytopathologic Findings

Zheng G. · Schmieg J. · Guan H. · Ali S.Z.
Departments of aPathology and bRadiology, The Johns Hopkins Hospital, Baltimore, Md., USA

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Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 7/6/2011 8:27:17 AM
Accepted: 8/24/2011
Published online: 2/17/2012
Issue release date: March–April

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY

Abstract

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematopoietic neoplasm, which in the past was also known variously as blastic NK cell lymphoma, agranular CD4+ natural killer cell leukemia, and CD4+/CD56+ hematodermic neoplasm. BPDCN is now believed to arise from plasmacytoid dendritic cells, but its exact etiology is still unknown. We report here on the cerebrospinal fluid (CSF) cytology of a BPDCN, a hypercellular specimen comprised of malignant, singly dispersed cells with scant to moderate amounts of pale blue, agranular cytoplasm, and uniform round to oval nuclei, fine chromatin, prominent nucleoli, occasional cytoplasmic microvacuoles, and pseudopodia. Neither mitoses nor karyorrhexis were identified. Flow cytometry of the CSF demonstrated that the malignant cells expressed bright CD45, HLA-DR and CD33, dim CD4, heterogeneous CD56, and partial CD123. The importance of clinical, histopathological, and phenotypic correlation is emphasized. Clinical and histopathological correlation and a literature review are also presented. The poor clinical outcome makes it important to accurately report this rare tumor in a CSF specimen.


  

Author Contacts

Correspondence to: Dr. Syed Z. Ali
Division of Cytopathology, Department of Pathology and Radiology
The Johns Hopkins Hospital, 600 North Wolfe Street (Room Path 406)
Baltimore, MD 21205 (USA)
Tel. +1 410 955 1180, E-Mail sali@jhmi.edu

  

Article Information

Received: July 6, 2011
Accepted after revision: August 25, 2011
Published online: February 17, 2012
Number of Print Pages : 5
Number of Figures : 3, Number of Tables : 0, Number of References : 14

  

Publication Details

Acta Cytologica (The Journal of Clinical Cytology and Cytopathology)

Vol. 56, No. 2, Year 2012 (Cover Date: February 2012)

Journal Editor: Bibbo M. (Philadelphia, Pa.)
ISSN: 0001-5547 (Print), eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY


Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 7/6/2011 8:27:17 AM
Accepted: 8/24/2011
Published online: 2/17/2012
Issue release date: March–April

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY


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