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Table of Contents
Vol. 73, No. 4, 2012
Issue release date: June 2012
Section title: Original Article
Gynecol Obstet Invest 2012;73:272–276
(DOI:10.1159/000332368)

Feasibility Study on Biweekly Paclitaxel Treatment as Maintenance Chemotherapy in Advanced Müllerian Carcinoma

Minagawa Y.a · Shimada M.b · Itamochi H.b · Sato S.b · Sato S.b · Okada M.a · Kitada F.d · Kigawa J.c
aDepartment of Obstetrics and Gynecology, Tottori Prefectural Central Hospital, Tottori, bDepartment of Obstetrics and Gynecology, Faculty of Medicine, Tottori University, and cTottori University Hospital Cancer Center, Yonago, and dDepartment of Obstetrics and Gynecology, Osaka Saiseikai Suita Hospital, Osaka, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: September 16, 2010
Accepted: August 17, 2011
Published online: March 01, 2012
Issue release date: June 2012

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 3

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Aim: To evaluate the feasibility of biweekly paclitaxel treatment as maintenance chemotherapy for patients with advanced müllerian carcinoma. Methods: Thirty patients with stage III or IV ovarian, fallopian tube, and peritoneal cancers who underwent primary optimal surgery and standard 6 cycles of carboplatin/taxane-based chemotherapy and exhibited a complete clinical response were entered in this study. Paclitaxel 80 mg/m2 was administered biweekly for 12 cycles. Patients were evaluated monthly for treatment-related toxicity. Results: Four patients, including 3 disease progressions and 1 bone marrow suppression, came off the protocol therapy. Twenty-six (86.7%) patients received complete treatment. Although the major toxicity was neutropenia, most of those patients (27/30, 90.0%) did not experience grade 3 or 4 neutropenia. Twenty-four (80.0%) patients showed persistent grade 1 neuropathy and the remaining 6 (20.0%) did not as a result of prior therapy. However, none experienced neuropathy progression during or after the protocol therapy. Most (17/22, 77.3%) of the completely treated patients experienced a regression of symptoms during and after therapy. Conclusion: Biweekly paclitaxel therapy is well tolerated by patients with advanced müllerian carcinoma and is therefore acceptable as a candidate for maintenance chemotherapy in these patients.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: September 16, 2010
Accepted: August 17, 2011
Published online: March 01, 2012
Issue release date: June 2012

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 3

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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