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Vol. 158, No. 3, 2012
Issue release date: June 2012
Section title: Position Paper
Int Arch Allergy Immunol 2012;158:216–231
(DOI:10.1159/000332924)

Severe Chronic Allergic (and Related) Diseases: A Uniform Approach – A MeDALL – GA2LEN – ARIA Position Paper

In collaboration with the WHO Collaborating Center for Asthma and Rhinitis
Allergy and Clinical Immunology, Department of Biomedical Sciences and Human Oncology, AO Mauriziano ‘Umberto I’, University of Turin, Turin, Italy

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Article / Publication Details

First-Page Preview
Abstract of Position Paper

Published online: 3/1/2012
Issue release date: June 2012

Number of Print Pages: 16
Number of Figures: 2
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.

© 2012 S. Karger AG, Basel


  

Author Contacts

Correspondence to: Prof. Jean Bousquet
Centre Hospitalier Universitaire, Montpellier
FR–34295 Montpellier Cedex 05 (France)
Tel. +33 611 42 88 47
E-Mail jean.bousquet@inserm.fr

  

Article Information

Published online: March 1, 2012
Number of Print Pages : 16
Number of Figures : 2, Number of Tables : 3, Number of References : 134

  

Publication Details

International Archives of Allergy and Immunology

Vol. 158, No. 3, Year 2012 (Cover Date: June 2012)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Position Paper

Published online: 3/1/2012
Issue release date: June 2012

Number of Print Pages: 16
Number of Figures: 2
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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