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Table of Contents
Vol. 227, No. 1, 2012
Issue release date: December 2011
Section title: EURETINA – Original Paper
Ophthalmologica 2012;227:39–44
(DOI:10.1159/000333213)

Long-Term Follow-Up of Myopic Choroidal Neovascularization Treated with Ranibizumab

Franqueira N.a · Cachulo M.L.a, b · Pires I.a, b · Fonseca P.a, b · Marques I.a · Figueira J.a, b · Silva R.a, b
aDepartment of Ophthalmology, University Hospital of Coimbra, and bAIBILI – Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal

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Article / Publication Details

First-Page Preview
Abstract of EURETINA – Original Paper

Received: September 06, 2011
Accepted: September 14, 2011
Published online: November 01, 2011
Issue release date: December 2011

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH

Abstract

Purpose: To evaluate the long-term safety and efficacy of intravitreal ranibizumab in the treatment of myopic choroidal neovascularization (CNV). Methods: Three-year retrospective, nonrandomized, interventional case series. Forty eyes of 39 patients with myopic CNV were included; 15 with previous photodynamic therapy, and 25 naïve eyes. Best-corrected visual acuity (BCVA) changes, central foveal thickness (CFT), and number of treatments were assessed, from baseline to month 36. Results: Mean visual acuity improved from 55.4 Early Treatment Diabetic Retinopathy Study (ETDRS) letters at baseline to 59.7 letters at 12 months (p = 0.07), 61.8 letters at 24 months (p = 0.008) and 63.4 letters at 36 months (p = 0.039). Twenty-five percent of the patients gained ≧15 letters (3 lines) at 12 months, 30% at 24 months and 35% at 36 months. There was a mean reduction of 80 µm in CFT (p < 0.001). A mean of 4.1 injections were performed in the first year, 2.4 in the second year and 1.1 in the third year. Fifty-three percent of the eyes had no need for treatment during the third year of follow-up. Conclusions: Intravitreal ranibizumab seems to be an effective and safe therapeutic procedure to treat CNV in highly myopic eyes, with a high proportion of patients gaining or stabilizing BCVA at a 3-year follow-up.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of EURETINA &#x2013; Original Paper

Received: September 06, 2011
Accepted: September 14, 2011
Published online: November 01, 2011
Issue release date: December 2011

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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