Signaling Pathways Governing Tumor AngiogenesisSakurai T. · Kudo M.
Department of Gastroenterology and Hepatology, Kinki University, Osakasayama, Japan
Angiogenesis is regulated by the highly coordinated function of various proteins with pro- and antiangiogenic functions. Proangiogenic factors include vascular endothelial growth factor (VEGF), fibroblast growth factor, platelet-derived growth factor, insulin-like growth factor, transforming growth factor, angiopoietins, and several chemokines; antiangiogenic factors include thrombospondin-1, angiostatin, and endostatin. Matrix metalloproteinases display a dual role in vascular development. Notch signaling affects remodeling of the primary vascular network of uniformly sized vessels into functionally and morphologically distinct arteries, veins, and capillaries. Tumors, described as ‘wounds that never heal’, lose the appropriate balance among these factors. Although VEGF-targeted therapies are showing promise, new angiogenesis targets are needed to make additional gains. Here, we highlight recent advances in our understanding of the regulation of tumor angiogenesis and discuss the potential of molecular targeting as a new therapeutic approach.
Masatoshi Kudo, MD
Department of Gastroenterology and Hepatology, Kinki University
377-2, Ohno-Higashi, Osakasayama 589-8511 (Japan)
Tel. +81 72 366 0221, ext. 3149
Published online: December 22, 2011
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 0, Number of References : 73
Oncology (International Journal for Cancer Research and Treatment)
Vol. 81, No. Suppl. 1, Year 2011 (Cover Date: December 2011)
Journal Editor: Markman M. (Philadelphia, Pa.)
ISSN: 0030-2414 (Print), eISSN: 1423-0232 (Online)
For additional information: http://www.karger.com/OCL