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Vol. 90, No. 1, 2012
Issue release date: February 2012
Section title: Clinical Study
Stereotact Funct Neurosurg 2012;90:30–36
(DOI:10.1159/000333839)

Effects of Relative Low-Frequency Bilateral Globus Pallidus Internus Stimulation for Treatment of Cervical Dystonia

Kim J.P. · Chang W.S. · Park Y.S. · Chang J.W.
Department of Neurosurgery, Severance Hospital, Brain Korea 21 Project for Medical Science, Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 4/25/2011 9:55:47 PM
Accepted: 9/28/2011
Published online: 1/6/2012

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 4

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN

Abstract

Objective: To assess the effect of relative lower amplitude and frequency for globus pallidus internus (GPi) deep brain stimulation (DBS) of cervical dystonia (CD). Materials and Methods: Between February 2005 and October 2008, 14 patients diagnosed with CD underwent bilateral GPi DBS and all the patients received low-frequency stimulation and were followed for more than 2 years. We activated the implantable pulse generator 3–4 days postoperatively and initial amplitude, pulse width, and frequency were set at 1.5 V, 120 µs, and 70 Hz. The Toronto Western Spasmodic Torticolis Rating Scale (TWSTRS) was applied preoperatively and at 1, 6, 12 and 24 months postoperatively. Results: The overall TWSTRS scores improved 71.2% 2 years postoperatively (p = 0.001). The mean improvement was 78.4% in severity subscores, 68.4% in disability, and 66.8% in pain scores for the 2-year follow-up period. The TWSTRS scores were significantly reduced (p < 0.05), suggesting that the most significant improvement of the TWSTRS scores occurred within 1 month. The final amplitude was 2.9/2.7 V with the pulse width of 147.9/147.9 µs and the frequency of 101.1/100 Hz. Conclusion: According to our results, the initial settings of low amplitude and especially relatively low frequency are safe and effective for treatment of CD.


  

Author Contacts

Jin Woo Chang, MD, PhD
Department of Neurosurgery
Yonsei University College of Medicine
134 Shinchon-Dong, Seodaemoon-Gu, Seoul 120-752 (Korea)
Tel. +82 2 2228 2159, E-Mail jchang@yuhs.ac

  

Article Information

Received: April 25, 2011
Accepted after revision: September 28, 2011
Published online: January 6, 2012
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 4, Number of References : 27

  

Publication Details

Stereotactic and Functional Neurosurgery

Vol. 90, No. 1, Year 2012 (Cover Date: February 2012)

Journal Editor: Roberts D.W. (Lebanon, N.H.)
ISSN: 1011-6125 (Print), eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 4/25/2011 9:55:47 PM
Accepted: 9/28/2011
Published online: 1/6/2012

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 4

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN


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