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Vol. 4, No. 3, 2011
Issue release date: September – December
Open Access Gateway
Case Rep Oncol 2011;4:512–516
(DOI:10.1159/000334080)
Published: October 2011

Mediastinal Choriocarcinoma Masquerading as Relapsed Hodgkin Lymphoma

Lam S.a · Rizkalla K.b · Hsia C.C.a
aDivision of Haematology, Department of Medicine and bDepartment of Pathology, London Health Sciences Centre, London, Ont., Canada

Abstract

Primary mediastinal choriocarcinoma is a rare extragonadal germ cell malignancy. We describe the first case of a patient who developed mediastinal choriocarcinoma after treatment for Hodgkin lymphoma (HL). A 25-year-old man with classic HL, nodular sclerosis subtype, underwent treatment with splenectomy followed by radiation therapy. Unfortunately, his disease relapsed with a paraspinal mass, and he was subsequently treated with MOPP (mechlorethamine, Oncovin, procarbazine, and prednisone) alternating with ABVD (Adriamycin, bleomycin, vinblastine, and dacarbazine). He achieved a complete remission after 6 cycles. Ten years after treatment, the patient presented with a persistent cough, haemoptysis, right supraclavicular lymphadenopathy, and weight loss. His chest X-ray showed opacification of the lower right hemithorax with a widened mediastinum. Given unresponsiveness to several antibiotics and lack of evidence for lung volume loss, there were concerns over lung infiltration with relapsed lymphoma. Transbronchial fine needle aspiration biopsy suggested recurrence of his HL. MOPP alternating with ABVD was again given. Due to disease progression, brachytherapy as well as a cocktail of dexamethasone, cytarabine, and cisplatin were also tried. However, on a subsequent excisional lymph node biopsy, it turned out that the tumour was in fact choriocarcinoma and not relapsed HL. Unfortunately, despite aggressive therapy, the patient’s disease rapidly progressed, and he died within 2 weeks.

 goto top of outline Author Contacts

Cyrus C. Hsia, MD, FRCPC
Division of Haematology, Department of MedicineLondon Health Sciences Centre, Room A2-401, Victoria Hospital800 Commissioners Road East, London, ON N6A 5W9 (Canada)
Tel. +1 519 685 8500, ext. 56059, E-Mail cyrus.hsia@lhsc.on.ca


 goto top of outline Article Information

Published online: October 14, 2011
Number of Print Pages : 5
Number of Figures : 3,


 goto top of outline Publication Details

Case Reports in Oncology

Vol. 4, No. 3, Year 2011 (Cover Date: September - December)

Journal Editor: Markman M. (Philadelphia, Pa.)
ISSN: NIL (Print), eISSN: 1662-6575 (Online)

For additional information: http://www.karger.com/CRO


Open Access License / Drug Dosage

Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
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