Prolonged Survival with Imatinib Mesylate Combined with Chemotherapy and Allogeneic Stem Cell Transplantation in de novo Ph+ Acute Myeloid LeukemiaSun J.a · Wang Z.b · Luo Y.a · Tan Y.a · Allan D.S.c · Huang H.a
aDepartment of Hematology, Bone Marrow Transplant Center, First Affiliated Hospital, College of Medicine, Zhejiang University, bThe Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China; cDivision of Hematology, The Ottawa Hospital, General Site, Ottawa, Ont., Canada
Background: De novo Philadelphia chromosome-positive (Ph+) acute myeloid leukemia (AML) is a rare disease with a poor prognosis. Imatinib mesylate (IM) is the standard treatment for Ph+ chronic myeloid leukemia and Ph+ acute lymphoblastic leukemia; however, its role in Ph+ AML has not been extensively investigated. Methods: Two patients aged of 46 and 19 years were diagnosed with de novo Ph+ AML according to the WHO Classification of Myeloid Neoplasms (2002) and the French-American-British (FAB) classification systems (1989). Cytogenetic analysis confirmed the presence of t(9;22). Standard RT-PCR was used to detect expression of the BCR-ABL1 fusion gene. Minimal residual disease was monitored by RQ-PCR for the BCR-ABL1/ABL ratio. Both patients received initial IM therapy combined with daunorubicin-based chemotherapy followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT) and IM maintenance treatment after allo-HSCT. Results: Both patients achieved long-term disease-free survival with complete hematologic response, complete molecular response, and complete cytogenetic response for 44 and 48 months, respectively. Conclusions: Our cases indicate that IM combined with daunorubicin-based chemotherapy followed by allo-HSCT and IM maintenance treatment is associated with a favorable outcome for de novo Ph+ AML, especially when IM is used in an early phase of AML.
© 2012 S. Karger AG, Basel
Jie Sun and Zhen Wang are co-first authors.
Received: June 15, 2011
Accepted after revision: October 3, 2011
Published online: January 12, 2012
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 2, Number of References : 16
Vol. 127, No. 3, Year 2012 (Cover Date: March 2012)
Journal Editor: Ben-Bassat I. (Qiryat-Ono)
ISSN: 0001-5792 (Print), eISSN: 1421-9662 (Online)
For additional information: http://www.karger.com/AHA